Review Article
Volume 8 Issue 11 - 2021
The Role of the Gut Microbiome in Defense against COVID-19
Igor E Khoroshilov*
Professor, Department of Anaesthesiology and Reanimatology Named After V. L. Vanevsky, Federal Public Budget Institution of Higher Education “North-Western State Medical University n. a. I. I. Mechnikov” of the Ministry of Health of the Russian Federation, Saint-Petersburg, Russia
*Corresponding Author: Igor E Khoroshilov, Professor, Department of Anaesthesiology and Reanimatology Named After V. L. Vanevsky, Federal Public Budget Institution of Higher Education “North-Western State Medical University n. a. I. I. Mechnikov” of the Ministry of Health of the Russian Federation, Saint-Petersburg, Russia.
Received: September 02, 2021; Published: October 29, 2021


The new coronavirus infection COVID-19, caused by the SARS-CoV-2 virus, was initially described as a “severe acute respiratory syndrome” leading to the development of fatal pneumonia. Later it was shown that the tropism of SARS-CoV-2 to the gastrointestinal epithelial cells is 100 times higher than in the respiratory tract, especially in the ileum. It has been established that although SARS-CoV-2 RNA elements are detected in the feces of patients, the virus itself is not there, and a fecal-oral route of transmission is impossible. In the lumen of the colon, viruses interacts with the gut microbiota and loses its infectivity. Perhaps it penetrates into the bacteria in the form of bacteriophages. We suggest using the virus’s tropism to intestinal cells to form immune defenses. The formation of immunity and immune memory occurs at the level of the ileum in Peyer’s plaques. If you inject a vaccine (RNA or attenuated live SARS-CoV-2) through the mouth into the small intestine, you can induce the development of intestinal symptoms and the formation of long-term immunity.

Keywords: New Coronavirus Infection COVID-19; SARS-Cov-2 Vaccine; Intestinal Microbiome; Immunity


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Citation: Igor E Khoroshilov. “The Role of the Gut Microbiome in Defense against COVID-19”. EC Gastroenterology and Digestive System 8.11 (2021): 108-114.

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