Mini Review
Volume 8 Issue 11 - 2021
Newly Discovered Brain Lymphatics Engender Fresh Possibilities of Delivering Lipid Soluble Nootropic Phytochemicals through Lymphatic Route
Sharadendu Bali1* and Randhir Singh2
1Professor of Surgery, MMIMSR, Mullana, Ambala, Haryana, India
2Professor, MM College of Pharmacy, MMDU, Mullana, Ambala
*Corresponding Author: Sharadendu Bali, Professor Surgery, MMIMSR, Mullana, Ambala, Haryana, India.
Received: October 04, 2020; Published: October 29, 2021


Drug delivery to the brain has always been purportedly troublesome and formidable, since the Blood-Brain Barrier (BBB) is believed to be preventing access. With the recent dismantling of the age-old neurological dogma of the brain being devoid of lymphatic circulation, the scope of delivering drugs to the brain has suddenly widened considerably. There is tremendous excitement in the pharmaceutical world, as the probability of delivering drugs to the brain through the nasal lymphatic communications opens up several new prospects. But nasal delivery to brain is just a sliver of the full realm of lymphatic delivery to the central nervous system: per-oral delivery of drugs and bioactives directed to the brain is a vastly more diverse field with enormous potentialities.

In fact, brain function promoting (nootropic) herbal formulations have been traditionally used in India for thousands of years. Most of these formulations use oils or fats (lipids) as the drug carrier. This pharmacologic drug delivery mechanism (using lipids as delivery system) is now being recognized as most suitable for phytochemicals, not only because most phytochemicals are lipophilic, but also because the lipoidic molecules, after oral ingestion are transported primarily by the lymphatic system. The rich inter-communications between cerebral and peripheral lymphatics renders the transport of these lipid-carried bioactives to the brain a very real possibility.

Keywords: Blood-Brain Barrier (BBB); Lipid Soluble Nootropic Phytochemicals; Lymphatic Route


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Citation: Sharadendu Bali and Randhir Singh. “Newly Discovered Brain Lymphatics Engender Fresh Possibilities of Delivering Lipid Soluble Nootropic Phytochemicals through Lymphatic Route”. EC Gastroenterology and Digestive System 8.11 (2021): 115-119.

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