Mini Review
Volume 8 Issue 12 - 2021
The Role of the Microflora of the Gastrointestinal Tract and Liver in the Pathogenesis of Obesity and Type 2 Diabetes

LA Zvenigorodskay1*, MV Shinkin1, AM Mkrtumyan1,2, TV Nilova1, AV Petrakov1 and SY Silvestrova1

1Moscow Clinical Scientific and Practical Center Named After A.S. Loginov, Moscow, Russia
2Moscow State Medical and Dental University Named After A.I. Evdokimov, Moscow, Russia
*Corresponding Author: LA Zvenigorodskay, Moscow Clinical Scientific and Practical Center Named After A.S. Loginov, Moscow, Russia.
Received: October 16, 2021; Published: November 19, 2021


Diabetes mellitus is the basis of polymorbidity. It is associated with various complications, primarily micro- and macrovascular, which often cause disability and death of patients. This disease is associated with an increased risk of developing certain types of cancer. Diabetes mellitus also causes the severe course and progression of non-alcoholic fatty liver disease, which remains an underestimated clinical problem. This pathology is usually diagnosed with severe clinical and functional disorders and the development of non-alcoholic steatohepatitis and cirrhosis of the liver.

Bile acid deficiency can lead to bacterial overgrowth syndrome, endotoxin-mediated chronic inflammation. Violation of the metabolic activity of bile acids also plays an important role in the pathogenesis of non-alcoholic fatty liver disease, which is the main reason for the ineffectiveness of treatment of many metabolic diseases, including type II diabetes mellitus.

The intestinal microbiome can interact with food components, affecting the body's sensitivity to insulin, intestinal permeability, glucose and fat metabolism. Obesity and type 2 diabetes mellitus are often characterized by changes in the intestinal microflora, inflammation and violation of the intestinal barrier. Thus, in patients with type 2 diabetes mellitus, there is an increase in the number of sulfate-reducing bacteria and a decrease in the number of Accegmapsia muciniphila - mucosal bacteria that are involved in the barrier function of the intestine. A decrease in the number of butyrate-producing bacteria may be the cause of impaired glucose metabolism.

Keywords: Type 2 Diabetes Mellitus; Microbiota; Short-Chain Fatty Acids; Non-Alcoholic Fatty Liver Disease


  1. Delzenne NM., et al. “Gut microorganisms as promising targets for the management of type 2 diabetes”. Diabetologia 10 (2015): 2206-2217.
  2. Grasset E., et al. “A specific gut microbiota dysbiosis of type 2 diabetic mice induces glp-1 resistance through an enteric no-dependent and gut-brain axis mechanism”. Cell Metabolism 1 (2017): 278.
  3. Kahn SE., et al. “Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future”. Lancet 9922 (2014): 1068-1083.
  4. Allin KH., et al. “Mechanisms in endocrinology: gut microbiota in patients with type 2 diabetes mellitus”. European Journal of Endocrinology 4 (2015): R167-R177.
  5. Ardatskaya M.D., et al. “Intestinal dysbiosis (dysbiosis): the current state of the problem, comprehensive diagnosis and therapeutic correction”. Experimental and Clinical Gastroenterology 5 (2015): 13-50.
  6. Igor Alexander Harsch and Peter Christopher Konturek. “The role of microbiota in the development of type 2 diabetes mellitus and obesity, as well as possible ways of correction”. Effective Pharmacotherapy Endocrinology22 (2019): 64-70.
  7. Martínez I., et al. “Long-term temporal analysis of the human fecal microbiota revealed a stable core of dominant bacterial species”. PLoS One7 (2013): e69621.
  8. Turnbaugh PJ., et al. “A core gut microbiome in obese and lean twins”. Nature7228 (2009): 480-484.
  9. Qin J., et al. “A human gut microbial gene catalogue established by metagenomic sequencing”. Nature7285 (2010): 59-65.
  10. Rey FE., et al. “Dissecting the in vivo metabolic potential of two human gut acetogens”. Journal of Biological Chemistry 29 (2010): 22082-22090.
  11. Kimura I., et al. “The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43”. Nature Communications 4 (2013): 1829.
  12. Eckburg PB., et al. “Diversity of the human intestinal microbial flora”. Science 5728 (2005): 1635-1638.
  13. Tamanai-Shacoori Z., et al. “Roseburia spp.: a marker of health?”. Future Microbiology 12 (2017): 157-170.
  14. Zvenigorodskaya LA., et al. “The role of the liver and the microflora of the gastrointestinal tract in the pathogenesis of type 2 diabetes mellitus and obesity”. Effective Pharmacotherapy 36 (2020): 32-42.
  15. Zvenigorodskaya LA., et al. “Promising methods of treatment of dyslipidemia in patients with NAFLD”. Clinical Pharmacology 3 (2019): 81-88.
  16. Ovsyannikova ON., et al. “Drug correction of atherogenic dyslipidemia in the elderly with coronary heart disease and gallbladder cholesterol”. Clinical Gerontology 1 (2006): 12-15.
  17. Venneman NG and Van Erpecum KJ. “Pathogenesis of gallstones”. Gastroenterology Clinics of North America 2 (2010): 171-183.
Citation: LA Zvenigorodskay., et al. “The Role of the Microflora of the Gastrointestinal Tract and Liver in the Pathogenesis of Obesity and Type 2 Diabetes”. EC Gastroenterology and Digestive System 8.12 (2021): 26-31.

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