Research Protocol
Volume 9 Issue 2 - 2022
Motor Function of the Gastrointestinal Tract in Gilbert’s Syndrome
Puzikov AM and Lychkova AE*
State Medical Institution Moscow Clinical Research Center Named After A. S. Loginov DZM, Moscow, Russia
*Corresponding Author: Lychkova AE, Department of Scientific and Patent-Inventive Work, State Medical Institution Moscow Clinical Research Center Named After A. S. Loginov DZM, Moscow, Russia.
Received: September 14, 2021; Published: January 28, 2022




Abstract

Introduction: Gilbert's syndrome is a genetically determined decrease in the uptake and conjugation of bilirubin.

Goal: The goal is to identify violations of the motor function of the gastrointestinal tract in the development of Gilbert's syndrome.

Materials and Methods: There were 12 patients with GS under observation: 5 men at the age of 24.7 ± 4.3 years and 7 women at the age of 21.4 ± 3.7 years. The motor function was studied electromyographically (EMG), the amplitude-frequency characteristics of slow waves and spikes, the power of phase and tonic contractions, propulsive activity were determined on the EMG curve using a hardware-software complex with a bandwidth of 0.01-10 kW. Statistical analysis was performed using the Mann-Whitney small sample method, M ± m, at p < 0.05.

Results: The increase in propulsive activity is due to the simultaneous increase in the frequency of slow waves and the frequency of spikes. a decrease in the motor function of the duodenum as a result of the possible development of bacterial overgrowth syndrome (SIBO), when excess microbial gas-forming flora contributes to the stretching of the intestinal wall and a decrease in motor function as a result of a decrease in the contacts of the actin-myosin complex. In the jejunum, bacterial overgrowth increases and propulsive activity is halved. The decrease in propulsive activity is due not only to the development of SIBO, but also to a decrease in the reabsorption of conjugated bile acids in Gilbert's syndrome. Complex disorders of the motility of the large intestine were revealed. The motility of the biliary system is multidirectional. The identified disorders of the motility of the digestive system are for the impairment of motor function characteristic of Gilbert's syndrome.

 

Keywords: Gilbert's Syndrome; Bilirubin; Gastrointestinal Tract

References

  1. SD Podymova. “Liver Diseases: A Guide for Physicians”. Edition. 5th, rev. and add. - Moscow: LLC "Medical Information Agency" (2018): 984.
  2. Lychkova AE. “Pacemakers of the upper parts of the digestive tract”. Bulletin of Experimental Biology and Medicine 156 (2013): 510-513.
  3. LB Lazebnik., et al. “Extrahepatic biliary rhythm drivers”. Bulletin of Experimental Biology and Medicine9 (2013): 352-354.
Citation: Puzikov AM and Lychkova AE. “Motor Function of the Gastrointestinal Tract in Gilbert’s Syndrome”. EC Gastroenterology and Digestive System 9.2 (2022): 14-17.

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