Research Article
Volume 9 Issue 4 - 2022
Treatment of Anxiety with Fecal Microbiota Transplantation: A Critical Review
Ana Pamela Gómez García1, María Magdalena Aguirre García1* and Álvaro Zamudio Tiburcio2*
1Unidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina, UNAM, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México
2Department of Gastroenterology, Intestinal Microbiota Transplantation Unit, (Medical Specialties Naples), Mexico City, Mexico
*Corresponding Author: María Magdalena Aguirre García, Unidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina, UNAM, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México and Álvaro Zamudio Tiburcio, Department of Gastroenterology, Intestinal Microbiota Transplantation Unit, (Medical Specialties Naples), Mexico City, Mexico.
Received: March 02, 2022; Published: March 15, 2021


Introduction: The significant relation between the intestinal microbiota and the brain is based on bidirectional communication through the microbiota-gut-brain axis. Anxiety can stem from an imbalance in this axis, together with other factors. Since about 15% of the world population suffers anxiety, it is necessary to seek effective solutions to what is now a growing public health issue. Fortunately, promising treatments for anxiety disorders are being developed. One prominent therapy is the restoration of the intestinal microbiota by intestinal microbiota transplantation (IMT).

Objective: To examine the advantages and disadvantages of treating anxiety with IMT by analyzing related articles.

Methods: An extensive search of the literature was conducted in the PubMed and Cochrane Library databases to find relevant reports published from 2015 - 2021. The following themes were sought in the abstract or title: IMT, anxiety, and various alternative treatments for modifying the intestinal microbiota.

Results: Of the 58 articles generated by the search, 7 were found to be suitable for the present review, considering the inclusion criteria. Four of the latter studies were quantitative, of which one was a clinical trial and the other three consisted of experiments on mice. All these quantitative studies considered fecal microbiota transplantation (FMT) to be advantageous for the treatment of anxiety.

Conclusion: FMT is useful for the clinical management of anxiety. The highly effective outcome far exceeds the importance of the few possible complications. Indeed, the majority of the complications are reversible. Avoiding the administration of antibiotics is recommended for this procedure.

Keywords: Anxiety; Intestinal Microbiota; Fecal Microbiota Transplantation; Microbiota-Gut-Brain Axis; Meta-Analysis


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Citation: María Magdalena Aguirre García., et al. “Treatment of Anxiety with Fecal Microbiota Transplantation: A Critical Review”. EC Gastroenterology and Digestive System 9.4 (2022): 17-22.

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