Case Report
Volume 7 Issue 1 - 2020
Radiotherapy of Hepatic Lymphoma
M Bahri*, H Ben Salah, H Daoud, T Sahnoun, L Farhat and J Daoud
Radiotherapy Department, Habib Bourguiba Hospital, University School of Medicine, Sfax, Tunisia
*Corresponding Author: M Bahri, Oncology Radiotherapy Service, CHU Habib Bourguiba, Sfax, Tunisia.
Received: November 1, 2019; Published: December 10, 2019


The objective of this work is to study the feasibility of a conformational liver radiotherapy through a clinical case with a review of the literature.

Observation: A 72-year-old patient was followed for large cell B lymphoma. Computed tomography scan revealed a mass of the V segment of the liver, measuring 10x14 cm, with peripheral and irregular enhancement of contrast and hepatic hilar and celio-mesenteric adenopathies of 3 cm. The liver test was normal. The LDH level was 602 IU/L.

She had 6 courses of chemotherapy type RCHOP 21. After chemotherapy hepatic mass measured 6x7x5 cm.

The patient received radiotherapy, using 3D conformal technique and delivering a dose of 39.6 Gy in 22 fractions. A ballistic with 4 beams of high energy (18 MV) was used. In dosimetry, the target volume was covered by 100% of the prescribed dose. The constraints on organs at risk (stomach, right kidney, spinal cord) have been respected. The average dose received by the healthy liver was 16 Gy. The volume of the liver receiving 5 Gy, 10 Gy, 15 Gy and 25 Gy was respectively 65%, 60%, 50% and 30%. After 3 years, the patient was alive without symptoms. The abdominopelvic CT showed a stable hepatic mass of 4X4X2 cm since the end of radiotherapy.

Conclusion: Hepatic conformational radiotherapy is feasible with a good clinical response and respect for the average dose received by the entire hepatic volume. New radiotherapy techniques can significantly reduce the dose received by the liver.

Keywords: Radiotherapy; Toxicity; CT


  1. Rio E., et al. “Radiothérapie des tumeurs hépatiques”. Cancer/Radiothérapie 20 (2016): S174-S178.
  2. Borgelt BB., et al. “The palliation of hepa- tic metastases: results of the Radiation Therapy Oncology Group pilot study”. International Journal of Radiation Oncology, Biology, Physics 7 (1981): 587-591.
  3. Olsen CC., et al. “Microscopic and macroscopic tumor and parenchymal effects of liver stereo- tactic body radiotherapy”. International Journal of Radiation Oncology, Biology, Physics 73 (2009): 1414-1424.
  4. Chang DT., et al. “Ste- reotactic body radiotherapy for colorectal liver metastases: a pooled analysis”. Cancer 117 (2011): 4060-4069.
  5. Feng M and Ben-Josef E. “Radiation therapy for hepatocellular carcinoma”. Seminars in Radiation Oncology 21 (2011): 271-277.
  6. Kubas A., et al. “Impact dosimé- trique du blocage respiratoire dans le traitement du carcinome hépatocellulaire par irradiation de conformation”. Radiation Therapy for Cancer 13 (2009): 24-29.
  7. Mornex F., et al. “Feasibility and efficacy of high-dose Three-dimensional-conformal radiotherapy in cirrhotic Patients with small-size hepatocellular carcinoma noneligible for curative therapies—mature results of the French phase ii rtf-1 trial”. International Journal of Radiation Oncology, Biology, Physics 66.4 (2006): 1152-1158.
  8. Liu MT., et al. “Three-dimensional conformal radiation therapy for unresectable hepatocellular carcinoma patients who had failed with or were unsuited for transcatheter arterial chemoembolization”. Japanese Journal of Clinical Oncology 34 (2004): 532-539.
  9. Wu FX., et al. “Efficacy of three-dimensional conformal radiotherapy combined with transarterial chemoembolization for hepatocellular carcinoma with portal vein tumor thrombus”. OncoTargets and Therapy 9 (2016): 7141-7147.
  10. Merle P., et al. “Innovative therapy for hepatocellular carcinoma: Three-dimensional high-dose photon radiotherapy”. Cancer Letters 286 (2009) 129-133.
  11. Zhao Q., et al. “Superiority of helical tomotherapy on liver sparing and dose escalation in hepatocellular carcinoma: a comparison study of three-dimensional conformal radiotherapy and intensity-modulated radiotherapy”. OncoTargets and Therapy 9 (2016): 3807-3813.
  12. Liang SX., et al. “Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver car¬cinoma: the risk factors and hepatic radiation tolerance”. International Journal of Radiation Oncology Biology Physics 65.2 (2006): 426-434.
  13. Cheng JC., et al. “Radiation-induced liver disease after radiotherapy for hepatocellular carcinoma: clinical manifestation and dosimetric description”. Radiotherapy and Oncology 63.1 (2002): 41-45.
Citation: M Bahri., et al. “Radiotherapy of Hepatic Lymphoma”. EC Gastroenterology and Digestive System 7.1 (2020): 01-04.

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