Case Report
Volume 10 Issue 5 - 2021
A Rare Coexistence of Uterine Lipoleiomyoma, Leiomyoma, Endometrial Polyp and Early Clear Cell Carcinoma of the Endometrium, Never Described Before
Helen J Trihia1*, Georgios Galanopoulos1, Efthymia Souka1, Loukas Karelis1, Alexandros Fotiou2 and Ioannis Provatas3
1Department of Pathology, ‘Metaxas’ Memorial Cancer Hospital, Piraeus, Greece
2Department of Gynecologic Oncology, ‘Metaxas’ Memorial Cancer Hospital, Piraeus, Greece
3Department of Pathology, Evangelismos District General Hospital, Athens, Greece
*Corresponding Author: Helen J Trihia, Consultant Pathologist, Department of Pathology, ‘Metaxas’ Memorial Cancer Hospital, Piraeus, Greece.
Received: March 20, 2021; Published: April 22, 2021


Background: Uterine lipoleiomyoma is a rare and specific type of leiomyoma being composed of benign smooth muscle cells admixed with mature adipocytes. These lesions may have coexistent malignancy in the uterus, ovaries and fallopian tubes, or may have other metabolic disorders and abnormal estrogen status.

Case Summary: Here, we report a case of a 66-year old female patient who was admitted to our hospital with irregular vaginal bleeding, due to atypical adenomatous hyperplasia, diagnosed on D&C (dilatation and curettage). A total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. Histopathological examination revealed rare occurrence of coexistent uterine lipoleiomyoma, leiomyoma, endometrial polyp and clear cell carcinoma of the endometrium.

Conclusion: Our findings are in accordance with that of other authors, in that lipoleiomyoma coexists with hyperestrogenic-related conditions and gynecologic malignancies. Clear cell carcinoma of the endometrium has not been previously described among co-existent malignancies. Although lipoleiomyomas have a favorable prognosis, the pathogenesis and clinical significance of these rare neoplasms need more clarification. The principal significance of these lesions is that they may have a coexistent malignancy.


Keywords: Lipoleiomyoma; Leiomyoma; Endometrial Polyp; Clear Cell Adenocarcinoma; Co-Existence


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Citation: Helen J Trihia., et al. “A Rare Coexistence of Uterine Lipoleiomyoma, Leiomyoma, Endometrial Polyp and Early Clear Cell Carcinoma of the Endometrium, Never Described Before”. EC Gynaecology 10.5 (2020): 93-101.

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