Case Report
Volume 10 Issue 5 - 2021
A Rare Coexistence of Uterine Lipoleiomyoma, Leiomyoma, Endometrial Polyp and Early Clear Cell Carcinoma of the Endometrium, Never Described Before
Helen J Trihia1*, Georgios Galanopoulos1, Efthymia Souka1, Loukas Karelis1, Alexandros Fotiou2 and Ioannis Provatas3
1Department of Pathology, ‘Metaxas’ Memorial Cancer Hospital, Piraeus, Greece
2Department of Gynecologic Oncology, ‘Metaxas’ Memorial Cancer Hospital, Piraeus, Greece
3Department of Pathology, Evangelismos District General Hospital, Athens, Greece
*Corresponding Author: Helen J Trihia, Consultant Pathologist, Department of Pathology, ‘Metaxas’ Memorial Cancer Hospital, Piraeus, Greece.
Received: March 20, 2021; Published: April 22, 2021




Abstract

Background: Uterine lipoleiomyoma is a rare and specific type of leiomyoma being composed of benign smooth muscle cells admixed with mature adipocytes. These lesions may have coexistent malignancy in the uterus, ovaries and fallopian tubes, or may have other metabolic disorders and abnormal estrogen status.

Case Summary: Here, we report a case of a 66-year old female patient who was admitted to our hospital with irregular vaginal bleeding, due to atypical adenomatous hyperplasia, diagnosed on D&C (dilatation and curettage). A total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. Histopathological examination revealed rare occurrence of coexistent uterine lipoleiomyoma, leiomyoma, endometrial polyp and clear cell carcinoma of the endometrium.

Conclusion: Our findings are in accordance with that of other authors, in that lipoleiomyoma coexists with hyperestrogenic-related conditions and gynecologic malignancies. Clear cell carcinoma of the endometrium has not been previously described among co-existent malignancies. Although lipoleiomyomas have a favorable prognosis, the pathogenesis and clinical significance of these rare neoplasms need more clarification. The principal significance of these lesions is that they may have a coexistent malignancy.

 

Keywords: Lipoleiomyoma; Leiomyoma; Endometrial Polyp; Clear Cell Adenocarcinoma; Co-Existence

References

  1. Wang X., et al. “Uterine lipoleiomyomas. A clinicopathologic study of 50 cases”. International Journal of Gynecological Pathology 25 (2006): 239-242.
  2. Aung T., et al. “Uterine lipoleiomyoma: A histopathological review of 17 cases”. Pathology International 54 (2004): 751-758.
  3. Shintaku M. “Lipomatous tumours of the uterus: A heterogeneous group? Histopathological study of five cases”. Pathology International 46 (1996): 498-502.
  4. Akbulut M., et al. “Giant lipoleiomyoma of the uterine corpus”. Archives of Gynecology and Obstetrics 278 (2008): 291-293.
  5. Kitajima K., et al. “MRI findings of uterine lipoleiomyoma correlated with pathological findings”. American Roentgen Ray Society 189 (2007): 100-104.
  6. Metin Akbulut., et al. “Clinical and Pathological Features of lipoleiomyoma of the uterine corpus: a review of 76 cases”. Balkan Medical Journal 31 (2014): 224-229.
  7. Bajaj P., et al. “Lipoleiomyoma of broad ligament. A case report”. Indian Journal of Pathology and Microbiology 3 (2004): 457-458.
  8. Kumar S., et al. “Lipoleiomyoma of uterus: uncommon incidental finding”. Obstetrics and Gynecology 3 (2013): 145.
  9. Sanjay Kumar., et al. “Lipoleiomyoma of uterus: uncommon incidental finding”. Obstetrics and Gynecology 3 (2013): 2.
  10. Akpolat I., et al. “ERRP-29 and ER staining in uterine lipoma and lipoleiomyoma”. Acta Oncologica 35 (1996): 108.
  11. Prieto A., et al. “Uterine lipoleiomyomas: US and CT findings”. Abdominal Imaging 25 (2000): 655-657.
  12. Chu CU., et al. “Diagnostic challenge of lipomatous uterine tumors in three patients”. World Journal of Radiology 4 (2012): 58-62.
  13. Lau LU and Thoeni RF. “Uterine lipoma: Advantage of MRI over ultrasound”. World Journal of Radiology 78 (2005): 72-74.
  14. Brandfass RT and Everts-Suarez EA. “Lipomatous tumours of the uterus: a review of the world’s literature with report of a case of true lipoma”. American Journal of Obstetrics and Gynecology 70 (1955): 359-367.
  15. Willen R., et al. “Lipomatous lesions of the uterus”. Virchows Archiv. A, Pathological Anatomy and Histopathology 377 (1978): 351-361.
  16. Sieinski W. “Lipomatous neometaplasis of the uterus: report of 11 cases with discussion of histogenesis and pathogenesis”. International Journal of Gynecological Pathology 8 (1989): 357-363.
  17. Fukunaga M. “Benign ‘metastasizing’ lipoleiomyoma of the uterus”. International Journal of Gynecological Pathology 22 (2003): 202-204.
  18. Wang Tatana Reslova Milan Resl. “The coincidence of pure lipoma, leiomyoma and endometrial cancer. A case report of the uterine tumor triplicity”. Acta Medica3 (2003): 129-130.
  19. Di Gesu G., et al. “Pure lipoma of the uterus in association with endometrial carcinoma”. European Journal of Obstetrics and Gynecology and Reproductive Biology 80 (1998): 199-200.
  20. Douvier S., et al. “The association of uterine lipoma and cancer of the endometrium. Diagnostic and etiopathogenic approach”. Journal of Gynecology Obstetrics and Human Reproduction 19 (1990): 301-305.
  21. Nilgun Sogutsu and Nazli Sena Seker. “Coexistence of uterine lipoma, leiomyoma and endometrial polyp”. Cukurova Medical Journal 3 (2019): 1139-1141.
Citation: Helen J Trihia., et al. “A Rare Coexistence of Uterine Lipoleiomyoma, Leiomyoma, Endometrial Polyp and Early Clear Cell Carcinoma of the Endometrium, Never Described Before”. EC Gynaecology 10.5 (2020): 93-101.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


May Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the May issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for upcoming Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before May 21, 2021.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to editor@ecronicon.uk