Research Article
Volume 10 Issue 5 - 2021
Use of Testicular Sperm Increases Fertility Outcome in Oligo-asthenoteratozoospermia Patients with Failed IVF/ICSI Cycle
Arzu Yurci*
Memorial Kayseri Hospital IVF Center, Gynecology Obstetrics & Reproductive Medicine, Kayseri, Turkey
*Corresponding Author: Arzu Yurci, Memorial Kayseri Hospital IVF Center, Gynecology Obstetrics & Reproductive Medicine, Kayseri, Turkey.
Received: March 31, 2021; Published: April 23, 2021




Abstract

Aim: To assess the impact of testicular sperm on fertility outcome in patient with oligo-asthenoteratozoospermia (OAT) who had previously failed ICSI cycles performed using ejaculated sperm.

Methods: 107 patients with a diagnosis of OAT and having at least two previous unsuccessful ICSI with ejaculated sperm were included in the study. Contrary to previous ICSI trials, it was decided to use testicular sperm in all cases this time. The primary outcome measures were fertilization rate (FR), ß hCG positivity, clinical pregnancy rate (CPR) and live birth rate (LBR).

Results: While fertilization was achieved in 17.4 out of of 107 couples using ejaculated sperm, 11 cases were positive for beta hCG and 5 cases were found to have heartbeats. Live birth did not occur in any of the patients who underwent ICSI with ejaculated sperm. In the testicular sperm group fertilization was detected in 44.6 of the embryos, beta-hCG positivity in 51 cases and CPR in 41 cases. Each parameter was found significantly higher than the ejaculated sperm group. Live birth was achieved in 36 patients using testicular sperm.

Conclusion: The use of surgically obtained testicular sperm significantly increased both CPR and LBR in OAT patients in whom pregnancy could not be achieved with ejaculated sperm.

Keywords: Intracytoplasmic Sperm Injection; Ejaculated Sperm; Microdissection Testicular Sperm Extraction; Apoptosis Score; Live Birth Rate

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Citation: Arzu Yurci. “Use of Testicular Sperm Increases Fertility Outcome in Oligo-asthenoteratozoospermia Patients with Failed IVF/ ICSI Cycle”. EC Gynaecology 10.5 (2021): 116-123.

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