Review Article
Volume 10 Issue 5 - 2021
Prenatal Diagnosis of Congenital Anterior Abdominal Wall Defects in Villa Clara, Cuba, 1994 - 2019: A Retrospective Analysis
Noel Taboada Lugo1*, Ana E Algora Hernández2, Gisela Noche González3, Manuela Herrera Martínez4, Lorna González Herrera5, Eliecer Anoceto Armiñana6 and Dagny de J Monteagudo Morales7
1Medical Doctor, Family Medicine Specialist, Clinical Genetics Specialist, Master’s Degree in Comprehensive Child Health, Associate Professor of the Medical University of Villa Clara, Cuba
2Medical Doctor, Clinical Genetics Specialist, Master´s Degree in Public Health, Associate Professor of the Medical University of Villa Clara, Cuba
3Medical Doctor, Family Medicine Specialist, Master´s Degree in Genetic Counseling, Associate of the Medical University of Villa Clara, Cuba
4Medical Doctor, Clinical Genetics Specialist, Doctorate in Medical Sciences, Full professor of the Medical University of Villa Clara, Cuba
5Medical Doctor, Terminal Professional Degree in Radiology, Assistant Professor of Medical Genetics at the Villa Clara Medical University, Cuba
6Medical Doctor, Pathological Anatomy Specialist, Associate Professor of the Medical University of Villa Clara, Cuba
7Medical Doctor, Family Medicine Specialist, Toxicomania Unit, Oviedo, Princedom of Asturias, Spain
*Corresponding Author: Noel Taboada Lugo, Medical Doctor, Family Medicine Specialist, Clinical Genetics Specialist, Master’s Degree in Comprehensive Child Health, Associate Professor of the Medical University of Villa Clara, Cuba.
Received: April 29, 2021; Published: May 05, 2021




Abstract

Objectives: To describe trends in prevalence of the abdominal wall defects, maternal age-specific prevalence and accuracy of prenatal diagnosis methods.

Methods: Retrospective analysis using data from Registries of Congenital Malformations in Villa Clara province, Cuba; from 1994 to 2019.

Results: The prevalence of abdominal wall defects was 8.47 per 10,000 live births. There was an increase of 34.6% of the overall prevalence. Gastroschisis had the highest increase (36.51%) from 4.30 to 5.87 per 10,000 live births. Gastroschisis was associated with an increased risk for youngest mothers (< 20 years of age) (OR = 3.78; CI = 1.64 - 3.37), whereas for omphalocele it was for women aged ≥ 35 years (OR = 4.22; CI = 2.3 - 7.78). The sensitivity of antenatal diagnosis of anterior abdominal wall defects by ultrasonography was 42.7% and by serum alpha-fetoprotein was 74.2%, with major accuracy of alpha-fetoprotein for gastroschisis (88.9%) and ultrasonography for omphalocele (65.9%) (p < 0,01 and p = 0, 01, respectively).

Conclusion: A rising prevalence trend has been noted in recent decades in Villa Clara. The present study revealed a pattern for young mothers of cases with gastroschisis and older maternal age for omphalocele. The use of fetal ultrasound and alpha-fetoprotein screening allowed the prenatal diagnosis of the majority of cases in Villa Clara.

 

Keywords: Prenatal Diagnosis; Abdominal Wall Defects; Gastroschisis; Omphalocele; Cuba

References

  1. Oakes MC., et al. “Advances in prenatal and perinatal diagnosis and management of gastroschisis”. Seminars in Pediatric Surgery 27 (2018): 289-299.
  2. Thakur M., et al. “A review on the role of vitamins in congenital ventral abdominal wall defects omphalocele and gastroschisis”. European Journal of Biomedical and Pharmaceutical Sciences 2 (2020): 66-76.
  3. Williams AP., et al. “Pentalogy of Cantrell”. Seminars in Pediatric Surgery 2 (2019): 106-110.
  4. Panaitescu AM., et al. “Ultrasound features and management of Body Stalk Anomaly”. Fetal Diagnosis and Therapy 4 (2016): 285-290.
  5. Taboada LN., et al. “Spatial-time clusters of neural tube defects and maternal alpha fetoprotein levels in Villa Clara province (2011-2015)”. Revista Cubana de Obstetricia y Ginecología 4 (2016): 451-663.
  6. Roblejo BH and Marcheco TB. “Genetics and genomic medicine in Cuba”. Molecular Genetics and Genomic Medicine 3 (2017): 196-201.
  7. Villa Clara Statistical Year Book. National Office of Statistic and Information. ONEI (2018).
  8. Stalling EB., et al. “Population-based birth defects data in the United States, 2012-2016: A focus on abdominal wall defects”. Birth Defects Research 18 (2019): 1436-1447.
  9. Marshall J., et al. “Prevalence, correlates, and outcomes of Omphalocele in the United States, 1995-2005”. Obstetrics and Gynecology 2 (2015): 284-293.
  10. Tan KBL., et al. “Gastroschisis and omphalocele in Singapore: A ten-year series from 1993 to 2002”. Singapore Medical Journal 1 (2008): 31-36.
  11. Kelay A., et al. “Congenital anterior abdominal defects”. Paediatric Surgery 12 (2016): 621-627.
  12. Safrida EN., et al. “Discharge outcomes of liveborn infants with omphalocele (Isolated Vs non-isolated)”. Malaysian Journal of Medicine and Health Sciences 3 (2020): 37-42.
  13. Grover R., et al. “Exomphalos without other prenatally detected anomalies: Perinatal outcomes from 22 years of population-based data”. Prenatal Diagnosis10 (2020): 1310-1314.
  14. Dubrovsky G., et al. “Understanding the relationship between hospital volume and patient outcomes for infants with gastroschisis”. Journal of Pediatric Surgery 12 (2017): 1977-1980.
  15. Ford K., et al. “Gastroschisis: Bellwether for neonatal surgery capacity in low resource settings?” Journal of Pediatric Surgery 8 (2016): 1262-1267.
  16. Prefumo F and Izzi C. “Fetal abdominal wall defects”. Best Practice and Research Clinical Obstetrics and Gynaecology 3 (2014): 391-402.
  17. Schmedding A., et al. “Decentralized surgery of abdominal wall defects in Germany”. Pediatric Surgery International 5 (2020): 569-578.
  18. Gright NJ., et al. “Care of infants with gastroschisis in low-resource settings”. Seminars in Pediatric Surgery 5 (2018): 321-326.
  19. Anderson JE., et al. “Epidemiology of gastroschisis: A population-based study in California from 1995 to 2012”. Journal of Pediatric Surgery 12 (2018): 2399-2403.
  20. Louis AM., et al. “Prevalence trends of selected major birth defects: a multi-state population-based retrospective study, United States, 1999 to 2007”. Birth Defects Research 109.18 (2017): 1442-1450.
  21. Jones AM., et al. “Increasing prevalence of gastroschisis-14 states, 1995-2012”. Morbidity and Mortality Weekly Report 2 (2016): 23-26.
  22. Given JE., et al. “Gastroschisis in Europe-A case-malformed-control study of medication and maternal illness during pregnancy as risk factors”. Paediatric and Perinatal Epidemiology 6 (2017): 549-559.
  23. Chen MC., et al. “Low and decreased prevalence of congenital abdominal wall defect in Taiwan”. Journal of Pediatric Surgery 9 (2019): 1958-1964.
  24. Li N., et al. “Decreasing prevalence and time trend of gastroschisis in 14 cities of Liaoning Province: 2006-2015”. Scientific Reports 6 (2016): 33333.
  25. Suita S., et al. “Changing profile of abdominal wall defects in Japan: results of a national survey”. Journal of Pediatric Surgery 1 (2000): 66-71.
  26. Bugge M., et al. “Abdominal wall defects in Greenland 1989-2015”. Birth Defects Research11 (2017): 836-842.
  27. Kirby RS. “The prevalence of selected major birth defects in the United States”. Seminars in Perinatology 6 (2017): 338-344.
  28. Gábor J., et al. “Abdominal wall malformations in a 15-year fetopathological study: accuracy of prenatal ultrasonography diagnosis”. Prenatal Diagnosis 11 (2010): 1015-1018.
  29. Watanabe S., et al. “Omphalocele and gastroschisis in newborns: over 16 years of experience from a single clinic”. Journal of Neonatal Surgery 2 (2017): 27.
  30. Calderon MG., et al. “Increasing prevalence, time trend and seasonality of gastroschisis in São Paulo state, Brazil, 2005-2016”. Scientific Reports 9 (2019): 14491-14501.
  31. Gonzalez KW and Chandler NM. “Ruptured omphalocele: Diagnosis and management”. Seminars in Pediatric Surgery 2 (2019): 101-105.
  32. Bener A and Mohamma RR. “Global distribution of consanguinity and their impact on complex diseases: Genetic disorders from an endogamous population”. Egyptian Journal of Medical Human Genetics 4 (2017): 315-320.
  33. Verla MA., et al. “Prenatal diagnosis and management of omphalocele”. Seminars in Pediatric Surgery 2 (2019): 84-88.
  34. Campaña H., et al. “Prenatal sonographic detection of birth defects in 18 hospitals from South America”. Journal of Ultrasound in Medicine 2 (2010): 203-212.
  35. Wesonga AS., et al. “Gastroschisis in Uganda: opportunities for improved survival”. Journal of Pediatric Surgery 11 (2016): 1772-1777.
  36. Hasan S., et al. “Outcome of gastroschisis in a developing country: Where to Focus?” Global Journal of Medical Research 1 (2017): 24-28.
Citation: Noel Taboada Lugo., et al. “Prenatal Diagnosis of Congenital Anterior Abdominal Wall Defects in Villa Clara, Cuba, 1994 - 2019: A Retrospective Analysis”. EC Gynaecology 10.6 (2020): 08-18.

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