Review Article
Volume 10 Issue 5 - 2021
Prenatal Diagnosis of Congenital Anterior Abdominal Wall Defects in Villa Clara, Cuba, 1994 - 2019: A Retrospective Analysis
Noel Taboada Lugo1*, Ana E Algora Hernández2, Gisela Noche González3, Manuela Herrera Martínez4, Lorna González Herrera5, Eliecer Anoceto Armiñana6 and Dagny de J Monteagudo Morales7
1Medical Doctor, Family Medicine Specialist, Clinical Genetics Specialist, Master’s Degree in Comprehensive Child Health, Associate Professor of the Medical University of Villa Clara, Cuba
2Medical Doctor, Clinical Genetics Specialist, Master´s Degree in Public Health, Associate Professor of the Medical University of Villa Clara, Cuba
3Medical Doctor, Family Medicine Specialist, Master´s Degree in Genetic Counseling, Associate of the Medical University of Villa Clara, Cuba
4Medical Doctor, Clinical Genetics Specialist, Doctorate in Medical Sciences, Full professor of the Medical University of Villa Clara, Cuba
5Medical Doctor, Terminal Professional Degree in Radiology, Assistant Professor of Medical Genetics at the Villa Clara Medical University, Cuba
6Medical Doctor, Pathological Anatomy Specialist, Associate Professor of the Medical University of Villa Clara, Cuba
7Medical Doctor, Family Medicine Specialist, Toxicomania Unit, Oviedo, Princedom of Asturias, Spain
*Corresponding Author: Noel Taboada Lugo, Medical Doctor, Family Medicine Specialist, Clinical Genetics Specialist, Master’s Degree in Comprehensive Child Health, Associate Professor of the Medical University of Villa Clara, Cuba.
Received: April 29, 2021; Published: May 05, 2021


Objectives: To describe trends in prevalence of the abdominal wall defects, maternal age-specific prevalence and accuracy of prenatal diagnosis methods.

Methods: Retrospective analysis using data from Registries of Congenital Malformations in Villa Clara province, Cuba; from 1994 to 2019.

Results: The prevalence of abdominal wall defects was 8.47 per 10,000 live births. There was an increase of 34.6% of the overall prevalence. Gastroschisis had the highest increase (36.51%) from 4.30 to 5.87 per 10,000 live births. Gastroschisis was associated with an increased risk for youngest mothers (< 20 years of age) (OR = 3.78; CI = 1.64 - 3.37), whereas for omphalocele it was for women aged ≥ 35 years (OR = 4.22; CI = 2.3 - 7.78). The sensitivity of antenatal diagnosis of anterior abdominal wall defects by ultrasonography was 42.7% and by serum alpha-fetoprotein was 74.2%, with major accuracy of alpha-fetoprotein for gastroschisis (88.9%) and ultrasonography for omphalocele (65.9%) (p < 0,01 and p = 0, 01, respectively).

Conclusion: A rising prevalence trend has been noted in recent decades in Villa Clara. The present study revealed a pattern for young mothers of cases with gastroschisis and older maternal age for omphalocele. The use of fetal ultrasound and alpha-fetoprotein screening allowed the prenatal diagnosis of the majority of cases in Villa Clara.


Keywords: Prenatal Diagnosis; Abdominal Wall Defects; Gastroschisis; Omphalocele; Cuba


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Citation: Noel Taboada Lugo., et al. “Prenatal Diagnosis of Congenital Anterior Abdominal Wall Defects in Villa Clara, Cuba, 1994 - 2019: A Retrospective Analysis”. EC Gynaecology 10.6 (2020): 08-18.

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