Mini Review
Volume 10 Issue 10 - 2021
The Possibility of Avoidance of Euploid Pregnancy Loss- Is it Feasible with the Utilization of Time Lapse Microscopy Only-A Short Communication
Kulvinder Kochar Kaur1*, Gautam Allahbadia2 and Mandeep Singh3
1Scientific Director, Centre for Human Reproduction, Jalandhar, Punjab, India
2Scientific Director, Ex-Rotunda-A Centre for Human Reproduction, Mumbai, India
3Neurology Consultant Neurologist, Swami Satyanand Hospital, Jalandhar, Punjab, India
*Corresponding Author: Kulvinder Kochar Kaur, Scientific Director, Centre for Human Reproduction, Jalandhar, Punjab, India.
Received: August 25, 2021; Published: September 21, 2021


Despite the utilization of preimplantation genetic testing (PGT) for aneuploidy (PGT-A), to rule out the chromosomal aberrations during an in vitro fertilization (IVF) that result in pregnancy losses along with Time lapse microscopy (TLM) for the avoidance of pregnancy loss following single euploid embryo transfer (ET) has still not become feasible. Thus, to further study the details of morphokinetic characteristics with the utilization of TLM, McQueen., et al. attempted a more detailed evaluation of the morphokinetic characteristics from time to syngamy to time to morula in addition to time to blastocyst generation. Subsequent to a single euploid embryo transfer with their studies of embryos which ended in an euploid abortion did not reveal any aberrant morphokinetic on the utilization of time lapse imaging. Hence as per their conclusions the etiology of euploid pregnancy loss is secondary to lot of factors that is inclusive of both embryo in addition to endometrial factors, with greater research required for finding the factors that can cause anticipation of as well as prevention of euploid loss. Apparently, the only answer lies in the use of Artificial Intelligence (AI), for this anticipation once available.

Keywords: Embryo Morphokinetic; In Vitro Fertilization (IVF); Time Lapse Imaging; Euploid Pregnancy Loss


  1. Levy B., et al. “Genomic imbalance in products of conception: single nucleotide polymorphism chromosomal microarray analysis”. Obstetrics and Gynecology 124 (2014): 202-209.
  2. Swai GE. “Could time lapse imaging reduce the need for biopsy and PGS?”. The Journal of Assisted Reproduction and Genetics 30 (2013): 1081-1090.
  3. Meseguer M., et al. “Embryo incubation and selection of time lapse monitoring system improves pregnancy outcome compared with a standard incubator: a retrospective cohort study”. Fertility and Sterility 98 (2012): 1481-1489.
  4. RienzlL Cimadomo D., et al. “Time of morulation and trophectoderm quality are predictors of after euploid embryo transfer: a multicenter study”. Fertility and Sterility 112 (2019): 1080-1093.
  5. Meseguer M., et al. “The use of morphokinetic as a predictor of embryo Implantation”. Human Reproduction 26 (2011): 2658-2671.
  6. ESHREWorking Group In time lapse Technology Apter S., et al. “Good practice recommendations for the use of time lapse”. Technology Human Reproduction Open (2020): hoaa008.
  7. MaQueen DB., et al. “Can embryo morphokinetic parameters predict euploid pregnancy loss?” Fertility and Sterility 115 (2021): 382-388.
  8. Motalo Y., et al. “Morphokinetic analysis and embryonic prediction for blastocyst formation”. Fertility and Sterility 105 (2016): 376-384.
  9. Meseguer M. “Euploidy prediction: possible or impossible? Closer or fartheraway?” Fertility and Sterility 115 (2021): 316-316.
  10. Kulvinder Kochar Kaur., et al. “Role of Artificial Intelligence with regards to improving success rate in human ‘’in vitro fertilization ‘’with emphasis on the blastocyst characteristics with respect to improving implantation, avoiding aneuploidy , for optimization of Live Birth rates’’-A Systematic Review”. Journal of Gynecologic Oncology1 (2021): 1-10.
  11. Kulvinder Kochar Kaur., et al. “Attempting Utilization of Precision Medicine in Addition to Artificial Intelligence in Reproductive medicine- An Introduction Along with their significance-A Review”. Perceptions in Reproductive Medicine3 (2021): 1-7.
Citation: Kulvinder Kochar Kaur., et al. “The Possibility of Avoidance of Euploid Pregnancy Loss- Is it Feasible with the Utilization of Time Lapse Microscopy Only-A Short Communication”. EC Gynaecology 10.10 (2021): 75-77.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

January Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the November issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before February 13, 2023.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.