Mini Review
Volume 10 Issue 10 - 2021
Marker-Based Approval of Immune Checkpoint Inhibitors
Chinmoy K Bose*
Department of Gynecologic Oncology and Department of Clinical Trial and Research, Netaji Subhas Chandra Bose Cancer Hospital, Nayabad Avenue, Kolkata, India
*Corresponding Author: Chinmoy K Bose, Department of Gynecologic Oncology and Department of Clinical Trial and Research, Netaji Subhas Chandra Bose Cancer Hospital, Nayabad Avenue, Kolkata, India.
Received: September 21, 2021; Published: September 30, 2021




Abstract

Advanced and recurrent endometrial cancer constitutes an unmet need as there is hardly any therapy available. Recent classification based on whole genome sequencing by the cancer genome atlas (TCGA) has shown deficient mismatch repair (dMMR) to be a factor. Resultant neoantigen causing change in local immunity has attracted immunotherapy as remedy. However, approval of such therapy based on dMMR and other few such marker based therapy approval by FDA is not received well as shown in post approval data published.

Keywords: dMMR; Immune Checkpoint Inhibitors; Endometrial Cancer; Pembrolizumab; Dostarlimab

References

  1. Drugs Approved for Endometrial Cancer.
  2. Talhouk A., et al. “Confirmation of ProMisE: A simple, genomics-based clinical classifier for endometrial cancer”. Cancer5 (2017): 802-813.
  3. GF Kerrest A and Dujon B. "Comparative genomics and molecular dynamics of DNA repeats in eukaryotes". Microbiology and Molecular Biology Reviews4 (2008): 686-727.
  4. Green AK., et al. “A Review of Immune Checkpoint Blockade Therapy in Endometrial Cancer”. American Society of Clinical Oncology Educational Book 40 (2020): 1-7.
  5. Evrard C and Alexandre J. “Predictive and Prognostic Value of Microsatellite Instability in Gynecologic Cancer (Endometrial and Ovarian)”. Cancers10 (2021): 2434.
  6. Le DT., et al. “PD-1 blockade in tumors with mismatch-repair deficiency”. The New England Journal of Medicine 372 (2015): 2509-2520.
  7. FDA grants accelerated approval to dostarlimab-gxly for dMMR endometrial cancer.
  8. Goodman AM., et al. “Microsatellite-Stable Tumors with High Mutational Burden Benefit from Immunotherapy”. Cancer Immunology Research10 (2019): 1570-1573.
  9. FDA grants accelerated approval to dostarlimab-gxly for dMMR advanced solid tumors.
  10. Khaki AR. “Loose Regulatory Standards Portend a New Era of Imprecision Oncology”. Cancer Investigation2 (2021): 120-123.
  11. Valero C., et al. “Response rates to anti-PD-1 immunotherapy in microsatellite-stable solid tumors with 10 or more mutations per megabase”. JAMA Oncology 7 (2021): 739-743.
  12. McGrail DJ., et al. “High tumor mutation burden fails to predict immune checkpoint blockade response across all cancer types”. Annals of Oncology 32 (2021): 661-672.
  13. Rousseau B., et al. “The spectrum of benefit from checkpoint blockade in hypermutated tumors”. The New England Journal of Medicine 384 (2021): 1168-1170.
  14. Marcus L., et al. “FDA Approval Summary: Pembrolizumab for the Treatment of Tumor Mutational Burden-High Solid Tumors”. Clinical Cancer Research17 (2021): 4685-4689.
Citation: Chinmoy K Bose. “Marker-Based Approval of Immune Checkpoint Inhibitors”. EC Gynaecology 10.10 (2021): 127-130.

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