Research Article
Volume 18 Issue 9 - 2022
Expression of TLR2 and TLR4 Receptors on Lymphoid Cells as a Marker of Infectious Lesions of Periodontal Tissues, Associated with the Dominance of Porphyromonas gingivalis and Filifactor alocis in Periodontal Biofilm

Tsarev Victor Nikolaevich1*, EN Nikolaeva1, IP Balmasova1,2, EV Ippolitov1, MS Podporin1 and EM Gretsov3

1Scientific Research Medical and Dental Institute, Moscow State University of Medicine and Dentistry, Moscow, Russia

2Department of Allergology and Immunology, Russian University of Friendship of Peoples of the World, Moscow, Russia

3Hematological Research Center of the Ministry of Public Health of Russia, Moscow, Russia

*Corresponding Author: Tsarev Victor Nikolaevich, Scientific Research Medical and Dental Institute, Moscow State University of Medicine and Dentistry, Moscow, Russia.
Received: September 08, 2021; Published: April 21, 2022


A research was carried out of the Toll-like receptors TLR2 and TLR4 expression on non-stimulated peripheral blood cells (neutrophils, monocytes and lymphocytes) and gingival fluid cells in people with healthy periodontal disease and in patients with chronic periodontitis associated with osteopenia and osteoporosis. P. gingivalis and F. alocis, asaccharolytic anaerobic bacteria, are emerging markers of periodontitis. It was established that the expression of TLR2 and TLR4 on peripheral blood leukocytes in different people, despite of their study group, varied significantly. Multidirectional expression of TLR2 and TLR4 on peripheral blood cells was found (both upward and downward) in patients with chronic periodontitis associated with P. gingivalis, F. alocis.


Keywords: TLR2; TLR4; Receptors; P. gingivalis; F. alocis; Periodontitis; Osteoporosis; Osteopenia


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Citation: Tsarev Victor Nikolaevich., et al. “Expression of TLR2 and TLR4 Receptors on Lymphoid Cells as a Marker of Infectious Lesions of Periodontal Tissues, Associated with the Dominance of Porphyromonas gingivalis and Filifactor alocis in Periodontal Biofilm”. EC Microbiology 18.9 (2022): 33-42.

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