Research Article
Volume 13 Issue 1 - 2021
Classical Music and Environmental Enrichment Enhanced Spatial Memory and Learning and Increased Mouse Innate Tendency to Avoid Open Spaces
Breno Raul Freitas Oliveira1, Tiago Werley Pires da Silva1, Raissa Maria Carvalho Alves1, José Ribamar Soares Neto1, Camila Araújo Oliveira1, Daniela Feliz Barbosa Guerreiro1, Mariana Mazza Santos1, Emanuel Ramos da Costa1, Cristovam Wanderley Picanço Diniz1* and Daniel Guerreiro Diniz1,2
1Universidade Federal do Pará, Instituto de Ciências Biológicas, Hospital Universitário João de Barros Barreto, Laboratório de Investigações em Neurodegeneração e Infecção, Belém, Pará, Brasil
2Instituto Evandro Chagas, Laboratório de Microscopia Eletrônica, Belém, Pará, Brasil
*Corresponding Author: Professor Cristovam Wanderley Picanço Diniz, Universidade Federal do Pará, Instituto de Ciências Biológicas, Hospital Universitário João de Barros Barreto, Laboratório de Investigações em Neurodegeneração e Infecção, Belém, Pará, Brasil.
Received: November 13, 2020; Published: December 30, 2020




Abstract

Little is known about combined effects of environmental enrichment and music stimulation on mice spatial learning and memory and on its innate repertoire to avoid open spaces. To investigate this question, 3 months aged BALB/c mice subjected to an environmental enriched (EE) or to an impoverished standard laboratory cage (IE) were exposed to random classical music (CM), three times a week, 12 h/day, three months, during the dark cycle, with an intensity of 65 dB. These groups were compared to control maintained in IE or EE but not exposed to music. All mice were then tested at the elevated plus maze (EPM), open field (OF) and Morris water maze (MWM). All tests were video recorded and analyzed using the Any-Maze®. A contrast index measured the relationship between the time spent in the periphery and the center of the open arena and between the closed and open arms of the EPM, and two-way ANOVA of these indices, showed significant influence of environment and music on the natural tendency to avoid open spaces. Of interest, was the significant increase in the time spent in the EPM closed arms of the EE/CM. All mice learned how to find and recall the hidden platform position before 7 days training. However, music stimulated EE mice, learned and recall the platform location faster than all other groups. In the open field test, it was found that the sound stimulus did not affect the locomotor behavior of these animals. Thus, the combination of an enriched environment and classical music stimulation seems to interact and enhance spatial learning and memory and increase the natural tendencies of BALB/c young mice to avoid open spaces.

Keywords: Classical Music; Enriched Environment; Spatial Learning And Memory; Open Field; Elevated Plus Maze; Morris Water-Maze

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Citation: Cristovam Wanderley Picanço Diniz., et al. “Classical Music and Environmental Enrichment Enhanced Spatial Memory and Learning and Increased Mouse Innate Tendency to Avoid Open Spaces”. EC Neurology 13.1 (2021): 12-20.

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