Research Article
Volume 13 Issue 1 - 2021
Serum Uric Acid Level and Its Effect on Short Term Functional Outcome of Acute Stroke and TIA: Prospective Single Center Study
Amal M Al Hashmi BSc, MD , FRCPC1*, Ahmed Al Saadi2, Mahmood Al Hinai2, Ahmed Al Sinani MD3, Sachin Jose4,  Noora  Al Jahwari5, Emma  Gallano5 and  Jaypee Sicat5
1Sr Consultant Neurologist, Chief Central Stroke Unit, Neuroscience Directorate, Khoula Hospital, Ministry of Health of Oman, Muscat, Oman
2Neurology Resident, Oman Medical Specialty Board OMSB, Muscat, Oman
3General Foundation Program Neurology, Oman Medical Specialty Board, Muscat, Oman
4Statistical Specialist, Oman Medical Specialty Board, Muscat, Oman
5Stroke Nurse at the Central Stroke Unit, Khoula Hospital, Muscat, Oman
*Corresponding Author: Amal M Al Hashmi BSc, MD , FRCPC, Sr Consultant Neurologist, Chief Central Stroke Unit, Neuroscience Directorate, Khoula Hospital, Ministry of Health of Oman, Muscat, Oman.
Received: November 07, 2020; Published: December 31, 2020




Abstract

Background: The association between high serum uric acid (SUA) level and cardiovascular diseases (CVD) such as stroke is not well established. Additionally, the effect of high SUA and stroke functional out- come and prognosis remains controversial. Further large-scale studies are needed. 

Objective: This study aims to assess the short-term  functional outcome  of patients admitted with acute stroke or  Transient Ischemic attack (TIA) and  elevated SUA. Additionally, it  aims to  deduce whether there is a trend  or a  relationship between the elevated SUA level, and stroke subtypes and TIA. 

Method: This is a  prospective observational single center hospital-based study performed at the Central Stroke Unit over 13 months period.  Starting January  2014 and ending January 2015. After obtaining the ethical approval by the hospital’s research committee; patient’s data was collected in an excel sheet.   The diagnosis of acute stroke or TIA for all included patients was confirmed by detailed history, examination, and brain imaging (CT or MRI).  Both ischemic and intracranial hemorrhage subtypes were included as well as TIA. Only confirmed acute stroke or TIA cases with SUA done withing 48 hours of admission date that  match all the inclusion and exclusion criteria were included.

Results: The final sample size was 187, they were 129, (69%) patients diagnosed with ischemic stroke (IS), 23 (12.3%) with intracranial hemorrhage (ICH) and 35(18.7%) with TIA. The mean age was 59.1 years of age. There were 111 men and 76 women. Elevated SUA was only found in 41 patients (36%) versus 73 (64%) patients with normal SUA level. There were 16 women with elevated SUA versus  25 men. Out of the 41 patients with elevated SUA and acute stroke or TIA; 26 had IS, and 10 had ICH and 5 with TIA.  The length of admission ranged between 4-11 days, with a median of 6 days. 70.3% of the patients had moderate to severe disability upon admission, versus 47.6% upon discharge. Nine patients (4.9%) were died.

Conclusions: In this study, although elevated SUA level was not associted with worsening short term functinal out come for patients  admitted with  acute stroke or TIA. It is  hard to draw a pricese conclusion due to the  small smaple size. Therefore further large scale and multicenter studies are needed.

Keywords: Serum Uric Acid;  Acute Stroke; Ischemic Stroke;  Intracranial Hemorrhage; Transient Ischemic Attack; Modified Rankin Scale

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Citation: Amal M Al Hashmi BSc., et al. “Serum Uric Acid Level and Its Effect on Short Term Functional Outcome of Acute Stroke and TIA: Prospective Single Center Study”. EC Neurology 13.1 (2021): 34-41.

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