Review Article
Volume 13 Issue 4 - 2021
The Potential Applicability of Melatonin as an Immunosuppressive Agent for COVID-19: Reviews
Leila A Pallante1,2, Dhir N Gala1,2*, Abdullah Egiz2, Sarvin Farajzadeh-Asl2 and Gautam Ullal3
1American University of the Caribbean School of Medicine, Sint Maarten
2School of Medicine, University of Central Lancashire, Preston, UK
3Professor of Neuroscience, American University of the Caribbean School of Medicine, Sint Maarten
*Corresponding Author: Dhir N Gala, American University of the Caribbean School of Medicine, Sint Maarten.
Received: February 16, 2021; Published: March 15, 2021




Abstract

COVID-19 is an emerging pathogen that has recently caused a global pandemic. It is an RNA virus that causes a respiratory tract infection. The pathogenesis of this virus involves an over aggressive immune reaction leading to inflammation and in certain cases acute respiratory distress syndrome (ARDS) and various neurological manifestations. Melatonin, a mitochondrially targeted antioxidant with anti-inflammatory properties, is being tested in trials as a potential adjuvant therapeutic agent that can help reduce oxidative stress damage caused by viral infections as well as optimizing the innate immune response. In addition, melatonin is an extremely safe drug and reports show its usefulness in treating other respiratory viral infections. The role of melatonin as an adjuvant in managing COVID-19 cases as well as the delirious states that are often encountered in these patients is being discussed.

Keywords: COVID-19; SARS-CoV-2; Melatonin; immunomodulation; Oxidative Stress; Prevention; Immunosuppression; Prophylaxis

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Citation: Dhir N Gala., et al. “The Potential Applicability of Melatonin as an Immunosuppressive Agent for COVID-19: Review”. EC Neurology 13.4 (2021): 11-21.

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