Review Article
Volume 13 Issue 4 - 2021
Strategical Initiatives in Schizophrenia Research: Beyond the Genetic Paradigm
Denis Larrivee*
Mind and Brain Institute, Loyola University Chicago, USA and Arts and Sciences, University of Navarra Medical School, Spain
*Corresponding Author: Denis Larrivee, Mind and Brain Institute, Loyola University Chicago, USA and Arts and Sciences, University of Navarra Medical School, Spain.
Received: March 01, 2021; Published: March 23, 2021


Despite decades of study - from whole genome studies to risk alleles and copy number variants - the genetic contribution to manifest schizophrenia symptoms remains an enigma. The absence of alignment implicates a tenuous and non-determinative link between genes and their observable effects in psychiatric behavior and a more plastic and subordinate role for genetics in cognition. Gaining increased traction as an explanans for the lack of correlation between gene influence and behavior is a broadly supported thesis that organismal behavior is structured to overcome limitations imposed by strictly deterministic, genetic influences so as to maximize behavioral variation and its control. That is, top down regulation enables and defines organismal behavior and in doing so employs genes and gene products as vehicles to this end. This apparent subordination of genetic influence on behavior favors top down strategical initiatives over genetic studies in schizophrenia research.

Keywords: Schizophrenia; Research Domain Criteria; Whole Genome Study; Cognitive Disease; Genetic Architecture; Psychosis


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Citation: Denis Larrivee. “Strategical Initiatives in Schizophrenia Research: Beyond the Genetic Paradigm”. EC Neurology 13.4 (2021): 40-45.

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