Research Article
Volume 13 Issue 8 - 2021
Randomized Controlled Trial of the Antinociceptive Effect of Menaquinone-7 (MK-7) in Patients with Peripheral Neuropathy
Dilip S Mehta1, Shashank S Jadhav1, Milind Devale2, Rama Vaidya3, Sidney J Stohs4 and Vladimir Badmaev5*
1Synergia Life Sciences Pvt. Ltd., Mumbai, India
22Kokan Hospital, Mumbai, India
33Medical and Research Centre, Kasturba Health Society, Mumbai, India
44School of Pharmacy and Health Professions, Creighton University, Omaha, Nebraska, USA
55Advisory Board of Synergia Life Sciences Pvt. Ltd., Staten Island, NY, USA
*Corresponding Author: Vladimir Badmaev, Advisory Board of Synergia Life Sciences Pvt. Ltd., Staten Island, NY, USA.
Received: June 02, 2021;Published: July 21, 2021




Abstract

A randomized, placebo-controlled double-blind pilot study was conducted to evaluate the efficacy and safety of menaquinone-7 (MK-7) in comparison to placebo in patients with peripheral neuropathy due to Type 2 diabetes mellitus (DN) or vitamin B12 deficiency (BN). A 100 µg capsule of MK-7 or identical placebo capsule was given twice daily for 8 weeks to 60 ambulatory patients of both genders to evaluate symptoms of peripheral neuropathy in DN and BN patients. The patients were followed for an additional 4 weeks (total of 12 weeks) and the intensity of the symptoms was self-assessed using a pain Visual Analog Scale (VAS).

There was a statistically significant decrease in the pain VAS score in DN and BN patients receiving MK-7 supplementation vs the corresponding placebo groups. The VAS pain score at baseline was on average approximately 8 to 9 out of 10. It was reduced to an average score of about 2 by week 12 in the DN and BN groups supplemented with MK-7 vs scores greater than 8 by week 12 in the placebo groups. The MK-7 was well-tolerated without subjective and objective adverse effects reported during the 8-week therapy and during the additional 4 weeks of follow-up.

Keywords: MK-7; Menaquinone-7; Type 2 Diabetes Mellitus; Vitamin B12 Deficiency; Peripheral Neuropathy; VAS Score

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Citation: Vladimir Badmaev., et al. “Randomized Controlled Trial of the Antinociceptive Effect of Menaquinone-7 (MK-7) in Patients with Peripheral Neuropathy”.EC Neurology 13.8 (2021): 01-10.

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