Short Communication
Volume 13 Issue 10 - 2021
NMDA Receptors as Key Players for Decision-Making in Neuron
Susumu Ito1,2*, Osamu Yokoi3 and Katsuhiko Hata2,3
1High-Tech Research Centre, Kokushikan University, Tokyo, Japan
2Department of Sports and Medical Science, Kokushikan University, Tokyo, Japan
3Department of Neuroscience, Research Centre for Mathematical Medicine, Tokyo, Japan
*Corresponding Author: Susumu Ito, High-Tech Research Centre, Kokushikan University, Tokyo, Japan.
Received: August 04, 2021; Published: September 07, 2021




Keywords: Long Term Potentiation; Long Term Depression; Critical Period; Tunnel Diode; Negative Resistance

N-methyl D-aspartate (NMDA) receptors are an important topic that has been mentioned frequently in neurology in recent years, and a number of articles in this journal have dealt with this topic even in the last few years only [1-6].

NMDA receptors are a type of ionotropic glutamate receptors consisting with 4 subunits [7]. NMDA receptors have several properties not found in other glutamate receptors. They require small amounts of glycine or D-serine as coagonist and have attachment sites for modifying agents such as Zn2+, phencyclidine (PCP) and polyamine, but the most distinctive and important feature is that they have low excitability due to channel blockade with Mg2+ at rest, whereas when activated they have considerable permeability to Ca2+. These two properties make NMDA receptors a kind of yes/no decision maker for the neuron. The intracellular fluids of cells including neurons in the resting state are almost Ca2+-free, and the influx of Ca2+ works as a signal for the initiation of cell-specific activities. Endocrine cells secrete endocrine, muscles contract and synaptic terminals of neurons secrete transmitters. NMDA receptors also work in the generation of neural oscillatory rhythms, such as swimming or walking [8].

References

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  3. Smit Shah., et al. “Anti N-Methyl D-Aspartate Receptor Encephalitis: Case Report and Literature Review”. EC Neurology3 (2018): 157-162.
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  10. Natalia Caporale and Yang Dan. “Spike Timing–Dependent Plasticity: A Hebbian Learning Rule”. Annual Review of Neuroscience1 (2008): 25-46.
  11. Elie L Bienenstock., et al. “Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex”. Journal of Neuroscience1 (1982): 32–48.
  12. Katsuhiko Hata., et al. “Multicoding in neural information transfer suggested by mathematical analysis of the frequency-dependent synaptic plasticity in vivo”. Scientific Reports13974 (2020).
  13. Xavier Leinekugel., et al. “Ca2+ Oscillations Mediated by the Synergistic Excitatory Actions of GABAA and NMDA Receptors in the Neonatal Hippocampus”. Neuron 2 (1997): 243-255.
  14. N B Sawtell., et al. “NMDA receptor-dependent ocular dominance plasticity in adult visual cortex”. Neuron 38 (2003) 977–98. Erratum Neuron 39 (2003): 727.
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Citation: Susumu Ito., et al. “NMDA Receptors as Key Players for Decision-Making in Neuron”. EC Neurology 13.10 (2021): 30-32.

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