Volume 13 Issue 10 - 2021
Acute-Onset Polyneuropathy Associated with SARS-CoV-2
Shan Liu1 and Hong-Liang Zhang2*
1Department of Neurology, First Hospital, Jilin University, Changchun, China
2Department of Life Sciences, National Natural Science Foundation of China, Beijing, China
*Corresponding Author: Hong-Liang Zhang, Department of Life Sciences, National Natural Science Foundation of China, Beijing, China.
Received: August 14, 2021; Published: September 25, 2021

The severe acute respiratory syndrome coronavirus (SARS-CoV)-2 that turned up in late 2019 is highly transmissible and marks the third zoonotic introduction of a highly pathogenic coronavirus into the human population [1]. The emergence of SARS-CoV-2 has caused the ongoing coronavirus disease 2019 (COVID-19) pandemic and has a disruptive impact on health and socioeconomics. The SARS-CoV-2, concordant with SARS-CoV-1 and Middle East respiratory syndrome coronavirus, belongs to the beta-coronaviruses family, which mainly infects the human respiratory system [2]. As the spike protein of SARS-CoV-2 has a receptor-binding domain with a stronger binding affinity for the angiotensin-converting enzyme 2 (ACE2) in the host cell surface, SARS-CoV-2 has higher transmissibility than SARS-CoV-1 [3]. The fusion of cell and membrane of SARS-CoV-2 is further facilitated by cleavage processing of the spike protein via the transmembrane protease serine 2 protease and cathepsin L host protease [2].


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Citation: Shan Liu and Hong-Liang Zhang. “Acute-Onset Polyneuropathy Associated with SARS-CoV-2”. EC Neurology 13.10 (2021): 74-77.

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