Review Article
Volume 14 Issue 2 - 2022
Brain to Mind - Cognitive and Emotional Journey within the Human Brain
CR Mukundan1* and C Kamarajan2
1Former Professor at NIMHANS, Bangalore and Professor Emeritus, at IBS, NFSU, Gandhinagar, Honorary Director, Brain Research Lab, Axxonet, Bangalore, India
2Assistant Professor, Department of Psychiatry, SUNY Downstate Health Sciences University, Brooklyn, NY, USA
*Corresponding Author: CR Mukundan, Former Professor at NIMHANS, Bangalore and Professor Emeritus, at IBS, NFSU, Gandhinagar, Honorary Director, Brain Research Lab, Axxonet, Bangalore, India.
Received: December 25, 2021; Published: January 11, 2022


The two fundamental functions of the human brain are the processes related to the domains of emotions and cognition. Under certain conditions, the rational part of the brain can be completely overtaken by the emotion-controlling centers of the brain. The “fight and flight” phenomenon seen in intense emotional behavior, was described as “amygdala hijacking” by Daniel Goleman [1] and “neural hijack” by LeDox [2,3]. The co-activation of both systems is always required to be carried out by any activity in day-to-day life. Both systems develop in every individual through social conditioning in the early years of development and growth of a child. Despite the scope for their integrative development and applications, there are many individuals all over the world, who resort to aggressive emotional responses because of the fact that they are not cognitively trained for emotional control, which is subserved by the frontalsubcortical circuits of the brain. It is also true that many such individuals do not possess cognitive maturity to rationally process social discomforts generated by spiritual-religious, cultural, personal conflicts, which could be amicably resolved through mature cognitive processing, which could help to emotionally adjust with the differences in their world views and lifestyles. Throughout human history, people have resorted to violence and war mainly for the sake of establishing their material gains and/or belief systems. Self-acceptance of emotionally supported and socially conducive ideas can help one to believe and accept the fact that supernatural forces controlling the self and the world outside are mere ideas and beliefs generated by our own brain. The religious dogmas and belief systems are basically the ideas created in our brains by self-suggestions, for the sake of supporting and helping people in stressful and conflicting conditions. When this basic fact is personally understood and accepted by the individuals, even though it may not be scientifically easy to be tested and proven, it will bring peace and harmony to the individual and to the world at large.

Keywords: Brain; Mind; Cognition; Emotion; Self-Molding


  1. Goleman D. “Emotional intelligence”. Bantam (2005).
  2. LeDoux J. "Emotional networks and motor control: a fearful view”. Progress in Brain Research 107 (1996): 437-446.
  3. LeDoux J. "Fear and the brain: where have we been, and where are we going?" Biological Psychiatry12 (1998): 1229-1238.
  4. LeDoux J. "The emotional brain, fear, and the amygdala”. Cellular and Molecular Neurobiology4-5 (2003): 727-738.
  5. Morris JS., et al. "Conscious and unconscious emotional learning in the human amygdala”. Nature6684 (1998): 467-470.
  6. Whalen PJ., et al. "Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge”. Journal of Neuroscience1 (1998): 411-418.
  7. Windmann S and Krüger T. "Subconscious detection of threat as reflected by an enhanced response bias”. Consciousness and Cognition4 (1998): 603-633.
  8. De Gelder B. "Nonconscious Emotions: New Findings and Perspectives on Nonconscious Facial Expression Recognition and Its Voice and Whole-Body Contexts”. Emotion and consciousness. New York, NY, US: The Guilford Press (2005): 123-149.
  9. De Gelder B and Rouw R. "Paradoxical configuration effects for faces and objects in prosopagnosia”. Neuropsychologia9 (2000): 1271-1279.
  10. De Gelder B., et al. "Covert processing of facial expressions in a blindsight patient”. Journal of Cognitive Neuroscience (1999).
  11. Vuilleumier P., et al. "Multiple levels of visual object constancy revealed by event-related fMRI of repetition priming”. Nature Neuroscience 5 (2002): 491-499.
  12. Pessoa L. "To what extent are emotional visual stimuli processed without attention and awareness?" Current Opinion in Neurobiology 2 (2005): 188-196.
  13. Bush G., et al. "Cognitive and emotional influences in anterior cingulate cortex”. Trends in Cognitive Sciences 6 (2000): 215-222.
  14. Devinsky O., et al. "Contributions of anterior cingulate cortex to behaviour”. Brain1 (1995): 279-306.
  15. Moruzzi G and Magoun HW. "Brain stem reticular formation and activation of the EEG”. Electroencephalography and Clinical Neurophysiology 4 (1949): 455-473.
  16. Mukundan C and Kacker P. "Emotional Arousal–the Driving Force of Life”. Journal of Psychology and Clinical Psychiatry 3 (2018): 00505.
  17. Luria AR. “Higher cortical functions in man. Higher cortical functions in man”. Oxford, England: Basic Books (1966).
  18. Luria AR. “Human brain and psychological processes”. Harper and Row (1966).
  19. Petrides M., et al. "Functional activation of the human frontal cortex during the performance of verbal working memory tasks”. Proceedings of the National Academy of Sciences, USA" 90 (1993): 878-882.
  20. Petrides M and Milner B. "Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man”. Neuropsychologia3 (1982): 249-262.
  21. Teuber H-L. "Space perception and its disturbances after brain injury in man: (For Wolfgang Köhler on his 75th birthday, January 21, 1962)”. Neuropsychologia1 (1963): 47-57.
  22. Teuber HL. "The riddle of frontal lobe function in man. 1964”. Neuropsychology Review1 (2009): 25-46.
  23. Cummings JL. "Frontal-subcortical circuits and human behavior”. Archives of Neurology8 (1993): 873-880.
  24. Hayden BY and Platt ML. "Neurons in anterior cingulate cortex multiplex information about reward and action”. Journal of Neuroscience9 (2010): 3339-3346.
  25. Alexander GE., et al. "Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor,“prefrontal” and “limbic” functions”. Progress in Brain Research 85 (1991): 119-146.
  26. Alexander GE., et al. "Parallel organization of functionally segregated circuits linking basal ganglia and cortex”. Annual Review of Neuroscience1 (1986): 357-381.
  27. Miller GA., et al. “Plans and the structure of behavior. Plans and the structure of behavior”. New York, NY, US: Henry Holt and Co (1960).
  28. Salmon E., et al. "Regional brain activity during working memory tasks”. Brain5 (1996): 1617-1625.
  29. Mukundan CR and Kamarajan C. "Brain to Mind: Creation of the Virtual World”. Advances in Social Sciences Research Journal 10 (2021): 513-544.
  30. Dolan RJ and Vuilleumier P. "Amygdala automaticity in emotional processing”. Annals of the New York Academy of Sciences 1 (2003): 348-355.
  31. Underwood R., et al. "Networks underpinning emotion: A systematic review and synthesis of functional and effective connectivity”. Neuroimage 243 (2021): 118486.
  32. Phan KL., et al. "Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI”. Neuroimage2 (2002): 331-348.
  33. Sergerie K., et al. "The role of the amygdala in emotional processing: a quantitative meta-analysis of functional neuroimaging studies”. Neuroscience and Biobehavioral Reviews4 (2008): 811-830.
  34. Okon-Singer H., et al. "Dynamic modulation of emotional processing”. Biological Psychology3 (2013): 480-491.
  35. Townsend JD., et al. "Frontal-amygdala connectivity alterations during emotion downregulation in bipolar I disorder”. Biological Psychiatry2 (2013): 127-135.
  36. Mochcovitch MD., et al. "A systematic review of fMRI studies in generalized anxiety disorder: evaluating its neural and cognitive basis”. Journal of Affective Disorders 167 (2014): 336-342.
  37. Jaworska N., et al. "A review of fMRI studies during visual emotive processing in major depressive disorder”. The World Journal of Biological Psychiatry7 (2015): 448-471.
  38. Morey R and Brown VM. "Neural systems for cognitive and emotional processing in posttraumatic stress disorder”. Frontiers in Psychology 3 (2012): 449.
  39. Beck AT. "Cognitive therapy: past, present, and future”. Journal of Consulting and Clinical Psychology2 (1993): 194-198.
  40. Ganis G., et al. "Brain areas underlying visual mental imagery and visual perception: an fMRI study”. Brain Research: Cognitive Brain Research2 (2004): 226-241.
  41. Kosslyn SM and Rosenberg RS. “Fundamentals of psychology: The brain, the person, the world”. Pearson Education New Zealand (2005).
  42. Kozhevnikov M., et al. "Spatial versus object visualizers: A new characterization of visual cognitive style”. Memory and Cognition4 (2005): 710-726.
  43. Sparing R., et al. "Visual cortex excitability increases during visual mental imagery-a TMS study in healthy human subjects”. Brain Research1-2 (2002): 92-97.
Citation: CR Mukundan and C Kamarajan. “Brain to Mind - Cognitive and Emotional Journey within the Human Brain”. EC Neurology 14.2 (2022): 01-08.

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