Review Article
Volume 14 Issue 9 - 2022
Dissociative Identity Disorder- A Forgotten Tale in Neuropsychiatry
Anushka Vashishth, Garima Sharma, Monika Kadian, Manish Jain and Anil Kumar*
Pharmacology Division, University Institute of Pharmaceutical Sciences (UIPS), UGC- Centre of Advanced Study (UGC-CAS), Panjab University, Chandigarh, India
*Corresponding Author: Anil Kumar, Professor of Pharmacology, Pharmacology Division, University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh, India.
Received: August 02, 2022; Published: August 29, 2022


Dissociative Identity Disorder is highly prevalent in clinical settings, generally undetected, with prevalence in the community as high as 1%. However, throughout the past few decades, progress in treating this condition has lagged behind than that in other psychiatric conditions. Individuals with dissociative disorders are one who had experienced childhood trauma and/or maltreatment more frequently than ones in any other psychiatric condition, and their dissociation is the pinnacle of human response to persistent developmental stress. An interruption in one or more mental functions is the essential component of dissociation. It also acts as a determinant in general psychiatry, including neurobiological and psycho-pharmacological studies. Despite the fact that dissociation may accompany nearly all mental disorders in addition to forming disorders in and of themselves, research on the topic has not been significant. Hence, this review aims to pour some light on the neglected area of DID, its prevalence, etiology, neurobiology, clinical appearance, diagnosis and clinical aspects.

Keywords: Dissociative Identity Disorder; Neurobiology; Post Traumatic Stress Disorder; Psychotherapy; Hypnotherapy; Pharmacological Intervention


  1. Şar Vedat., et al. “Revisiting the etiological aspects of dissociative identity disorder: a biopsychosocial perspective”. Psychology Research and Behavior Management 10 (2017): 137-146.
  2. International Society for the Study of Trauma and Dissociation. “Guidelines for treating dissociative identity disorder in adults, third revision”. Journal of Trauma and Dissociation: The Official Journal of the International Society for the Study of Dissociation (ISSD)2 (2011): 115-187.
  3. Sar Vedat. "Epidemiology of dissociative disorders: An overview”. Epidemiology Research International 2011 (2011).
  4. Paris Joel. “The rise and fall of dissociative identity disorder”. The Journal of Nervous and Mental Disease12 (2012): 1076-1079.
  5. “Dissociative Identity Disorder (Multiple Personality Disorder): Signs, Symptoms, Treatment”.
  6. Dorahy Martin J., et al. “Dissociative identity disorder: An empirical overview”. The Australian and New Zealand Journal of Psychiatry5 (2014): 402-417.
  7. Forrest KA. “Toward an etiology of dissociative identity disorder: a neurodevelopmental approach”. Consciousness and Cognition3 (2001): 259-293.
  8. Shore Allan N. "Affect dysregulation and disorders of the self”. New York: WW (2003).
  9. Sar Vedat., et al. "Frontal and occipital perfusion changes in dissociative identity disorder”. Psychiatry Research: Neuroimaging3 (2007): 217-223.
  10. Sar Vedat., et al. "HMPAO SPECT study of regional cerebral blood flow in dissociative identity disorder”. Journal of Trauma and Dissociation2 (2001): 5-25.
  11. Lapointe AR., et al. "Similar or disparate brain patterns? The intra-personal EEG variability of three women with multiple personality disorder”. Clinical EEG and Neuroscience3 (2006): 235-242.
  12. Hughes John R., et al. "Brain mapping in a case of multiple personality”. Clinical Electroencephalography4 (1990): 200-209.
  13. Hopper Annedore., et al. "EEG coherence and dissociative identity disorder: Comparing EEG coherence in DID hosts, alters, controls and acted alters”. Journal of Trauma and Dissociation1 (2002): 75-88.
  14. Rutkofsky IH., et al. "The neuropsychiatry of dissociative identity disorder: why split personality patients switch personalities intermittently”. Journal of Cell Science and Therapy 2 (2017): 1-8.
  15. Van Der Hart., et al. "Memory fragmentation in dissociative identity disorder”. Journal of Trauma and Dissociation1 (2005): 55-70.
  16. Vermetten Eric., et al. "Hippocampal and amygdalar volumes in dissociative identity disorder”. American Journal of Psychiatry4 (2006): 630-636.
  17. Reinders Antje ATS and Dick J Veltman. "Dissociative identity disorder: out of the shadows at last?” The British Journal of Psychiatry2 (2021): 413-414.
  18. Brand Bethany L., et al. "Separating fact from fiction: An empirical examination of six myths about dissociative identity disorder”. Harvard Review of Psychiatry (2016).
  19. Kluft Richard P. "An overview of the psychotherapy of dissociative identity disorder”. American Journal of Psychotherapy3 (1999): 289-319.
  20. Spiegel David. "Hypnosis in the treatment of victims of sexual abuse”. Psychiatric Clinics of North America2 (1989): 295-305.
  21. Loewenstein Richard J. "Rational psychopharmacology in the treatment of multiple personality disorder”. Psychiatric Clinics of North America (1991).
  22. Braun Bennett G. "Multiple personality disorder and posttraumatic stress disorder”. International Handbook of Traumatic Stress Syndromes. Springer, Boston, MA (1993): 35-47.
  23. Braun Bennett G. "Unusual medication regimens in the treatment of dissociative disorder patients: I. Noradrenergic agents”. Dissociation: Progress in the Dissociative Disorders (1990).
  24. Putnam Frank W. “Diagnosis and treatment of multiple personality disorder”. Guilford Press (1989).
  25. Torem Moshe S. “Psychopharmacology”. Handbook of Dissociation (1996): 545-566.
Citation: Anil Kumar., et al. “Dissociative Identity Disorder- A Forgotten Tale in Neuropsychiatry”. EC Neurology 14.9 (2022): 15-24.

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