Research Article
Volume 2 Issue 9 - 2020
Standardized Nursing Care Plan for Patients with Metastatic Neuroendocrine Tumor and Radiometabolic Therapy with 177Lutetium-Dotatate
Inmaculada Bonilla Aguilar1*, Ester Cabrera Saavedra2, Immaculada Ferrero Febrer3, Paz Fernández-Ortega4, María Magdalena López Jiménez5 and Ma Antonia Martínez-Momblán6
1Nurse Manager Image Diagnosis, Hospital Universitari de Bellvitge, Institut Català de la Salut, Hospitalet de Llobregat, Spain
2Nurse Supervisor Image Diagnosis, Hospital Universitari de Bellvitge, Institut Català de la Salut, Hospitalet de LLobregat, Spain
3Nurse Superviror Image Diagnosis, Hospital Universitari de Bellvitge, Institut de Diagnòstic per la Imatge, Hospitalet de Llobregat, Spain
4Research Coordinating Nurse, Catalan Institute of Oncology, Hospitalet de Llobregat, Professor University of Barcelona, Spain
5Nurse, Information Systems Nurse Support Unit, Hospital Universitari de Bellvitge, Institut Català de la Salut, Hospitalet de Llobregat, Spain
6Professor, Department of Fundamental Nursing and Medical-Surgical, Universitat de Barcelona, Hospitalet de Llobregat, Spain
*Corresponding Author: Inmaculada Bonilla Aguilar, Nurse Manager Image Diagnosis, Hospital Universitari de Bellvitge, Institut Català de la Salut, Hospitalet de Llobregat, Spain.
Received: February 25, 2020; Published: August 29, 2020


Objective: The general objective is to describe the nursing care and possible complications of patients with neuroendocrine tumor treated with 177Lutetium-Dotatate at the Day Hospital of the Nuclear Medicine Service of the Hospital Universitari de Bellvitge.

Method: A description is made of the standardized procedure of nursing work in patients with metastatic neuroendocrine tumor treated with 177Lutetium-Dotatate admitted to the Nuclear Medicine Service of the Hospital Universitari de Bellvitge.

Results: The specialized nurse of radiometabolic therapy performs the reception of the patient. She is responsible for the correct preparation of the patient and administration of 177Lutetium-Dotatate. Performs vital signs and the insertion of two peripheral catheters to administer premedication, amino acids and 177Lutetium-Dotatate. The nurse controls the possible complications: the risk of multiorgan toxicity, the risk of heteroirradiation, the risk of local reaction in the area of administration and the risk of anxious depressive syndrome.

Conclusion: The standardization of nursing care ensures the quality of health care in patients with metastatic neuroendocrine tumor who are treated with 177-Lutetium. The nurse individualizes the care through clinical judgment and performing interventions such as support for decision-making, counseling, information, strengthening of safety, reducing the number of unnecessary procedures, reducing variability in clinical practice and the accompaniment to the patient.

Keywords: Neuroendocrine Tumors; Lutetium Dotatate; Nursing Care and Specialized nurse


  1. Hallet J., et al. “Exploring the rising incidence of neuroendocrine tumors: A population-based analysis of epidemiology, metastatic presentation, and outcomes”. Cancer 121.4 (2015): 589-597. 
  2. Singh S., et al. “Diagnosis and management of gastrointestinal neuroendocrine tumors: An evidence-based Canadian consensus”. Cancer Treatment Reviews 47 (2016): 32-45. 
  3. Yao JC., et al. “One hundred years after “carcinoid”: Epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States”. Journal of Clinical Oncology 26.18 (2008): 3063-3072. 
  4. Zaknun JJ., et al. “The joint IAEA, EANM, and SNMMI practical guidance on peptide receptor radionuclide therapy (PRRNT) in neuroendocrine tumours”. European Journal of Nuclear Medicine and Molecular Imaging 40.5 (2013): 800-816. 
  5. Van Der Zwan JM., et al. “Rare neuroendocrine tumours: Results of the surveillance of rare cancers in Europe project”. European Journal of Cancer 49.11 (2013): 2565-2578. 
  6. Garcia-Carbonero R., et al. “Incidence, patterns of care and prognostic factors for outcome of gastroenteropancreatic neuroendocrine tumors (GEP-NETs): Results from the National Cancer Registry of Spain (RGETNE)”. Annals of Oncology 21.9 (2010): 1794-1803. 
  7. Vinik A and Feliberti E PR. “Carcinoid Tumors” (2014). 
  8. Chung C. “Management of neuroendocrine tumors”. American Journal of Health-System Pharmacy 73.21 (2016): 1719-1744. 
  9. Gurusamy K., et al. “Palliative cytoreductive surgery versus other palliative treatments in patients with unresectable liver metastases from gastro-entero-pancreatic neuroendocrine tumours (Review)”. The Cochrane Database of Systematic Reviews 1 (2009):1-11. 
  10. Pearman TP., et al. “Health-related quality of life in patients with neuroendocrine tumors: an investigation of treatment type, disease status, and symptom burden”. Support Care Cancer 24.9 (2016): 3695-3703. 
  11. Strosberg J., et al. “Phase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors”. The New England Journal of Medicine 376.2 (2017): 125-135. 
  12. JuvéUdina ME (en nom de les persones components del Grup Ares). Plans de cures estandaritzats per a malalts hospitalitzats. Programa ARES d’harmonització d’estàndards de cures dels hospitals de l’Institut. Generalitat de Catalunya, Departament de Salut. Institut Català de la Salut”. Català de la Salut. 1a edició (2013): 3872.
  13. Roca M., et al. “Reglamento de funcionamiento unidad asistencial de Medicina Nuclear”. Institut Diagnòstic per la Imatge, Hospital Universitari de Bellvitge. IRA 2629 (2016). 
  14. Vercher JL., et al. “Teràpia Radiometabòlica amb Luteci-177-Dotatate de Tumors Neuroendocrins”. Unitat Medicina Nuclear/PET. Hospital Universitari de Bellvitge (2016). 
  15. Bouvier C. “Nurse developments in neuroendocrine tumour management”. Endocrine-Related Cancer 10.4 (2003): 487-488. 
  16. Haugland T., et al. “Improvement in Stress, General Self-Efficacy, and Health Related Quality of Life following Patient Education for Patients with Neuroendocrine Tumors: A Pilot Study”. Nursing Research and Practice (2013): 695820. 
  17. Martini C., et al. “Systematic review reveals lack of quality in reporting health-related quality of life in patients with gastroenteropancreatic neuroendocrine tumours”. Health Quality and Life Outcomes 14.1 (2016): 127. 
  18. Haugland T., et al. “Association between general self-efficacy, social support, cancer-related stress and physical health-related quality of life: a path model study in patients with neuroendocrine tumors”. Health Quality and Life Outcomes 14.1 (2016): 11. 
Citation: Inmaculada Bonilla Aguilar., et al. “Standardized Nursing Care Plan for Patients with Metastatic Neuroendocrine Tumor and Radiometabolic Therapy with 177Lutetium-Dotatate”. EC Nursing and Healthcare 2.9 (2020): 98-102.

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