Research Article
Volume 3 Issue 4 - 2021
High Serum Uric Acid Levels in Preeclampsia and Perinatal Outcome
Ram Prasad Sapkota1*, Subodh Raj Dawadi2, Srijana Pandey Gaire2 and Surya Gaire3
1Senior Consultant Obstetrician and Gynaecologist, Bharatpur Hospital, Chitwan, Nepal
2Consultant Obstetrician and Gynecologist, Bharatpur Hospital, Chitwan, Nepal
3Bir Hospital Nursing Campus, National Academy of Medical Sciences, Kathmandu, Nepal
4Independent Researcher, Nepal
*Corresponding Author: Ram Prasad Sapkota, Senior Consultant Obstetrician and Gynaecologist, Bharatpur Hospital, Chitwan, Nepal.
Received: February 27, 2021; Published: March 30, 2021


Hypertensive disorders of pregnancy are the most frequent medical condition that comes across during pregnancy and the medical and economic burden of the condition on the women and society is very high. The working group of the NHBPEP- National High Blood Pressure Education Program classified hypertensive disorders of pregnancies as: Gestational Hypertension, preeclampsia and eclampsia syndrome, preeclampsia superimposed on chronic hypertension and chronic hypertension. Uric acid is a product of purine degradation catalyzed by the enzyme xanthine oxidase and in humans most circulating uric acid is produced in the liver. Uric acid concentrations are influenced by several factors like high protein diet, alcohol consumption, and increased cell turn over, enzyme defects in purine metabolism, altered kidney function, etc. The serum level of uric acid rises preceding the signs and symptom of preeclampsia. Various biomarkers have been tried to predict the outcomes of preeclamptic pregnancies but poor sensitivity and specificity.

The objective of this study is to find the relation of raised uric acid and fetal outcome in preeclamptic women, to estimate serum uric acid levels in preeclampsia and to compare the fetal outcome of preeclampsia with normal uric acid and raised uric acid level in terms of Birth weight, APGAR scores, NICU admissions. This study is a hospital based prospective case control study conducted at Paropakar Maternity and Women's Hospital, Thapathali, Kathmandu with total 92 sample size taken for study. There was a total of 5003 obstetric admission and a total of 429 hypertensive disorders of pregnancies were identified.  There was a total of 183 preeclamptic cases and among those cases only 92 patients that met the inclusion criteria were enrolled into the study. The incidence of hypertensive disorder was found to be 8.5%. Adverse perinatal outcomes in preeclamptic patients with serum uric acid more than 5.5mg/dl had 17% low birth weight, 11% NICU admission and 30% had low APGAR score. And the amount of low birth weight observed was statistically significant. Hypertensive disorders of pregnancy are common medical disorders affecting 5 to 10% of pregnancies. These are associated with adverse perinatal outcomes. The Incidence of hypertensive disorder in current study was 8.5%. Perinatal morbidity in terms of low birth weight, NICU admissions and Low APGAR scores were higher in preeclamptic patients with serum uric acid more than 5.5mg/dl. But only the difference in low birth weight was statistically significant.


Keywords: Adverse Perinatal Outcome; Preeclampsia; Serum Uric Acid; Hypertensive Disorder; Nepal


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Citation: Ram Prasad Sapkota., et al. “High Serum Uric Acid Levels in Preeclampsia and Perinatal Outcome”. EC Nursing and Healthcare 3.4 (2021): 105-112.

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