Research Article
Volume 16 Issue 5 - 2021
Effect of Weight Loss on Pro-inflammatory Cytokines Post Sleeve Gastrectomy among Obese Children and Adolescents
Alanoud Aladel1*, Adel A Alhamdan1, F Khan1, Asim A Siddiqui1 and Aayed Alqahtani2
1Community Health Sciences, Collage of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia
2Department of Biostatistics, Obesity Research Chair, College of Medicine, King Saud University, Riyadh, Saudi Arabia
*Corresponding Author: Alanoud Aladel, Community Health Sciences, Collage of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Received: March 18, 2021; Published: April 29, 2021




Abstract

Introduction: Low-grade inflammation is a common occurrence in obesity, type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). In obesity, increased levels of interleukins and other inflammatory cytokines in the circulation may partly reflect a spillover from the adipose tissue.

Methodology: A prospective study was carried out to assess the levels of pro-inflammatory factors (TNF-α, IL-1β, and IL-6), dietary intake, fasting blood glucose and lipid profile before and 6 months after sleeve gastrectomy (SG), among 21 morbidly obese children and adolescents aged ≤ 18 years.

Results: Subjects achieved significant decrease in all anthropometric measurements and sleep apnea 6 months after SG. A significant increase in high density lipoprotein (HDL) and a significant decrease in fasting glucose (FG) levels and IL-1β levels was observed 6 months post-surgery (p ≤ 0.05). The reductions in body mass index (BMI), hip circumference and triglyceride (TG) levels significantly correlated with IL-6 concentrations and the reduction in hip circumference and mid arm circumference correlated significantly with IL-1β levels post-surgery. Linear regression showed the role of BMI and energy intake to predict the decreased level of IL-1β after surgery.

Conclusion: Sleeve gastrectomy represents a safe method for downregulating the inflammatory state that could lead to CVD and insulin resistance (IR) in obese children and adolescents. The significant decrease in IL-1β, increase in HDL and resolution of sleep apnea after SG can reduce CVD risk factors among morbidly obese children and adolescent, whereas the significant decrease in FG can reduce IR risk factors.

 

Keywords: Inflammation; Sleeve Gastrectomy; Cytokines; Obesity

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Citation: Alanoud Aladel., et al. “Effect of Weight Loss on Pro-inflammatory Cytokines Post Sleeve Gastrectomy among Obese Children and Adolescents”. EC Nutrition 16.5 (2021): 03-14.

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