Review Article
Volume 16 Issue 7 - 2021
Latent Tuberculosis Infection, Possibilities of Diagnosis and Treatment in Patients with HIV Infection
Russkikh Oleg Evgenevich*
Associate Professor, Head of the Department of Phthisiology, Izhevsk State Medical Academy of the Ministry of Health of the Russian Federation, Izhevsk, Russia
*Corresponding Author: Russkikh Oleg Evgenevich, Associate Professor, Head of the Department of Phthisiology, Izhevsk State Medical Academy of the Ministry of Health of the Russian Federation, Izhevsk, Russia.
Received: April 27, 2021; Published: July 30, 2021


The review presents domestic and foreign literature data on current issues of latent tuberculosis infection (LTBI) and its role in the risk of developing tuberculosis in different population groups, including patients with HIV infection. It has been shown that the greatest risk of developing tuberculosis in persons with LTBI occurs with HIV infection: the annual risk of developing tuberculosis increases by 10%. In the diagnosis of latent tuberculosis infection, allergic skin tests (Mantoux and Diaskintest test), detection of MBT antigens (PCR) and antibodies (ELISA) and in vitro tests based on the production of γ-interferon under the action of various MBT antigens are currently used in the Russian Federation. Based on the results obtained, the tactics and treatment regimen for LTBI were determined. The review presents the main information obtained by domestic and foreign researchers on the results of LTBI treatment to reduce the risk of developing tuberculosis in HIV-infected patients. The article discusses topical issues of chemoprophylaxis of tuberculosis in HIV patients with LTBI, which presents effective treatment regimens aimed at reducing the risk of reactivation of tuberculosis infection, reducing the drug load on the patient and the development of adverse reactions.

The acquisition of new knowledge on the LTBI problem will contribute to the solution of an important task - control over the progression of tuberculosis in HIV-infected patients.

Keywords: Latent Tuberculosis Infection; Chemoprophylaxis; Allergic Skin Tests; Combined Tuberculosis; HIV Infection; LTBI Treatment


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Citation: Russkikh Oleg Evgenevich. “Latent Tuberculosis Infection, Possibilities of Diagnosis and Treatment in Patients with HIV Infection”. EC Nutrition 16.8 (2021): 39-45.

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