Research Article
Volume 16 Issue 12 - 2021
Evaluation of the Gastrointestinal Tolerability of Fibersmart®, a Novel Dietary Fiber, Using a Randomized Controlled Trial in Healthy Men and Women

Shaun Y M Teo1,2* and Timothy J Fairchild1,2

1Discipline of Exercise Science, Murdoch University, Perth, WA, Australia
2Associate Professor, Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, WA, Australia
*Corresponding Author: Shaun Y M Teo, Discipline of Exercise Science, Murdoch University, Perth, WA, Australia.
Received: October 05, 2021; Published: November 30, 2021


Dietary fiber is integral to a healthful diet and the promotion of dietary fiber remains a key global health priority. Despite these efforts, most of the global population do not meet the dietary fiber intake recommendations. FiberSmart® is a type of resistant starch which may be added to food products to increase their dietary fiber content. The purpose of this randomized controlled trial was to determine the gastrointestinal (GI) tolerability of FiberSMART® consumption in generally healthy study volunteers. Forty generally healthy adults were randomized and allocated into either the intervention (n = 20; 27.8 ± 8.0 years; BMI: 26.6 ± 4.4; female: 8) or control (n = 20; 28.4 ± 11.4 years; BMI: 24.5 ± 4.6; female: 7) condition. Each group completed three phases of seven days each, separated by a 21-day wash-out. Participants in the intervention condition received an escalating dose of 10 g/day, 30 g/day and 50 g/day of FiberSMART® consumed in a single dose on each day, while those in the control condition received placebo (flavored drink without addition of FiberSMART®) on each day. Thirty-eight participants completed the trial (n = 19 in each condition). There were no significant between-group differences (p = .376) in the GI composite score over the three phases, and the reported symptoms were mild overall. Additionally, GI symptoms did not appear to increase across the escalating doses, which was supported by additional measures of GI tolerability including stool characteristics and self-reported quality of life. A dietary fiber supplement with good tolerability, as demonstrated in these studies of FiberSMART® in generally healthy adults, is of relevance to public health strategies aiming to increase global dietary fiber content.

Keywords: Dietary Fiber; Dietary Fibre; Health; Controlled Trial; RCT


  1. Soliman GA. “Dietary Fiber, Atherosclerosis, and Cardiovascular Disease”. Nutrients5 (2019): 1155.
  2. Trowell H. “Ischemic heart disease and dietary fiber”. The American Journal of Clinical Nutrition 9 (1972): 926-932.
  3. Trowell HC. “Dietary-fiber hypothesis of the etiology of diabetes mellitus”. Diabetes8 (1975): 762-765.
  4. Dwyer JT., et al. “Dietary fiber and fiber supplements in the therapy of gastrointestinal disorders”. The Journal of the Maine Medical Association2 (1978): 51-60.
  5. Kritchevsky D. “Metabolic effects of dietary fiber”. Western Journal of Medicine2 (1979): 123-127.
  6. Anderson JW. “The role of dietary carbohydrate and fiber in the control of diabetes”. Advances in Internal Medicine 26 (1980): 67-96.
  7. Weickert MO and AF Pfeiffer. “Metabolic effects of dietary fiber consumption and prevention of diabetes”. Journal of Nutrition3 (2008): 439-442.
  8. Bandera EV., et al. “Association between dietary fiber and endometrial cancer: a dose-response meta-analysis”. The American Journal of Clinical Nutrition6 (2007): 1730-1737.
  9. Cupisti A., et al. “Nutritional treatment of advanced CKD: twenty consensus statements”. Journal of Nephrology4 (2018): 457-473.
  10. Livingstone KM and SA McNaughton. “Association between diet quality, dietary patterns and cardiometabolic health in Australian adults: a cross-sectional study”. Journal of Nutrition1 (2018): 19.
  11. Yoneoka D., et al. “Does Japan's national nutrient-based dietary guideline improve lifestyle-related disease outcomes? A retrospective observational cross-sectional study”. PLoS One10 (2019): e0224042.
  12. Fayet-Moore F., et al. “Dietary Fibre Intake in Australia. Paper I: Associations with Demographic, Socio-Economic, and Anthropometric Factors”. Nutrients5 (2018).
  13. McGill CR., et al. “Healthy Eating Index-2010 and food groups consumed by US adults who meet or exceed fiber intake recommendations NHANES 2001-2010”. Food and Nutrition Research 60 (2016): 29977.
  14. Hunt KJ., et al. “Daily Eating Frequency in US Adults: Associations with Low-Calorie Sweeteners, Body Mass Index, and Nutrient Intake (NHANES 2007-2016)”. Nutrients 9 (2020).
  15. Miketinas DC., et al. “Usual Dietary Intake of Resistant Starch in US Adults from NHANES 2015-2016”. Journal of Nutrition 10 (2020): 2738-2747.
  16. King DE., et al. “Trends in dietary fiber intake in the United States, 1999-2008”. Journal of the Academy of Nutrition and Dietetics 5 (2012): 642-648.
  17. Dai FJ and CF Chau. “Classification and regulatory perspectives of dietary fiber”. Journal of Food and Drug Analysis 1 (2017): 37-42.
  18. Labeling OoNaF. “Review of the Scientific Evidence on the Physiological Effects of Certain Non-Digestible Carbohydrates”. C.f.F.S.a.A.N. U.S., Editor (2018).
  19. Boler BM., et al. “Digestive physiological outcomes related to polydextrose and soluble maize fibre consumption by healthy adult men”. British Journal of Nutrition12 (2011): 1864-1871.
  20. Crincoli CM., et al. “Evaluation of the gastrointestinal tolerability of corn starch fiber, a novel dietary fiber, in two independent randomized, double-blind, crossover studies in healthy men and women”. International Journal of Food Sciences and Nutrition7 (2016): 844-856.
  21. Russo J., et al. “The MOS 36-Item Short Form Health Survey: reliability, validity, and preliminary findings in schizophrenic outpatients”. Medical Care5 (1998): 752-756.
  22. Ware JE., et al. “The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection”. Medical Care6 (1992): 473-483.
  23. Windisch W., et al. “Evaluation of health-related quality of life using the MOS 36-Item Short-Form Health Status Survey in patients receiving noninvasive positive pressure ventilation”. Intensive Care Medicine4 (2003): 615-621.
  24. Hull S., et al. “Consuming polydextrose in a mid-morning snack increases acute satiety measurements and reduces subsequent energy intake at lunch in healthy human subjects”. Appetite3 (2012): 706-712.
Citation: Shaun Y M Teo and Timothy J Fairchild. “Evaluation of the Gastrointestinal Tolerability of Fibersmart®, a Novel Dietary Fiber, Using a Randomized Controlled Trial in Healthy Men and Women”. EC Nutrition 16.12 (2021): 28-36.

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