Research Article
Volume 11 Issue 8 - 2020
House Dust Mite Immunoglobulin G Antibodies in Patients with Allergic Conjunctivitis
Tatsuya Mimura1,2*, Aki Kondo2, Hidetaka Noma3 and Atsushi Mizota1
1Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan
2Department of Ophthalmology, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan
3Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan
*Corresponding Author:Tatsuya Mimura, Department of Ophthalmology, Teikyo University School of Medicine, and Department of Ophthalmology, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan.
Received: June 11, 2020; Published: July 30, 2020




Abstract

Purpose: To examine the role of IgG in perennial allergy, we evaluated the relation between perennial allergic conjunctivitis and serum levels of specific IgG antibodies for HDM.

Methods: A prospective study was conducted in patients with seasonal allergic conjunctivitis (seasonal group, N = 10), patients with perennial allergic conjunctivitis (perennial group, N = 10) and control subjects (control group, N = 10). Serum levels of specific IgE and IgG antibodies for HDM were measured, as well as the total IgE level in tear fluid (total tear IgE), and a skin prick test was performed. Changes of the palpebral/bulbar conjunctiva and limbal or corneal lesions associated with allergic conjunctivitis were assigned a score (0 - 3), and the total conjunctivitis score was calculated (0 - 30).

Results: Serum HDM-specific IgG antibody levels were higher in the perennial group than the seasonal group (3.5 ± 0.5 vs. 1.3 ± 1.1), but there was no significant difference of HDM-specific IgE between the two groups (1.4 ± 0.7 vs. 1.4 ± 0.5). Multivariate analysis demonstrated that the mean wheal diameter in the skin prick test and the total conjunctivitis score were related to the serum level of HDM-specific IgG (odds ratio [OR] = 5.4, p < 0.01 and OR = 23.4, p < 0.01), but not to the serum level of HDM-specific IgE (OR = 1.4, p = 0.68 and OR = 0.4, p = 0.35).

Conclusion: The serum HDM IgG antibody level was more closely associated with allergic manifestations than the HDM IgE antibody level. Measurement of specific IgG antibodies may be helpful for detecting allergens responsible for perennial allergic diseases.

Keywords: Allergic Conjunctivitis; House Dust Mite; Seasonal Allergy; Specific Ige; Specific Igg; Perennial Allergy

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Citation: Tatsuya Mimura., et al. “House Dust Mite Immunoglobulin G Antibodies in Patients with Allergic Conjunctivitis”. EC Ophthalmology 11.8 (2020): 26-39.

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