Literature Review
Volume 12 Issue 6 - 2021
Melatonin and Osteoarthritis: An Overlooked Mediator?
Ray Marks*
Department of Health and Behavior Studies, Teachers College, Columbia University, NY, United States
*Corresponding Author: Marks Ray, Department of Health and Behavior Studies, Teachers College, Columbia University, New York, NY, United States.
Received: May 12, 2021; Published: May 24, 2021




Abstract

Introduction: Osteoarthritis, a prevalent chronic disabling disease, is also an independent risk factor for COVID-19 infections among the elderly.

Aim: To examine what is known about the endocrine hormone melatonin and its possible utility for intervening in the osteoarthritis disability cycle, potentially heightened in the context of COVID-19 and its persistence and restrictions.

Methods: The PUBMED electronic data base was searched in its entirety, from 1992 - 2021 using the key terms: melatonin and osteoarthritis.

Results: Very few clinical studies on this topic prevail, even though almost all preclinical studies imply a favorable role for melatonin in enhancing osteoarthritis pathology, as well as COVID-19 immunity. Conversely, a deficit in melatonin appears associated with many features of osteoarthritis pathology, as well as its extra-articular symptoms, such as impaired sleep.

Conclusion: Melatonin has potent antioxidant, analgesic, regenerative, and anti-inflammatory properties that should be studied further in the context of efforts to improve the outlook for many older osteoarthritis sufferers, especially those residing in the community, and affected by the COVID-19 pandemic lockdown restrictions.

Keywords: Articular Cartilage; Bone; COVID-19; Inflammation; Melatonin; Osteoarthritis; Pain; Prevention

References

  1. Hong Y., et al. “Salutary effects of melatonin combined with treadmill exercise on cartilage damage”. Journal of Pineal Research1 (2014): 53-66.
  2. Hatfield GL., et al. “The association between knee joint muscle activation and knee joint moment patterns during walking in moderate medial compartment knee osteoarthritis: implications for secondary prevention”. Archives of Physical Medicine and Rehabilitation (2021): S0003-9993(21)00334-338.
  3. Endstrasser F., et al. “The negative impact of the COVID-19 lockdown on pain and physical function in patients with end-stage hip or knee osteoarthritis”. Knee Surgery Sports Traumatology and Arthroscopy 8 (2020): 2435-2443.
  4. Garrido-Cumbrera M., et al. “Assessment of impact of the COVID-19 pandemic from the perspective of patients with rheumatic and musculoskeletal diseases in Europe: results from the REUMAVID study (phase 1)”. Rheumatic and Musculoskeletal Diseases Open 1 (2021): e001546.
  5. Markus RP., et al. “Immune-pineal axis - acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes”. British Journal of Pharmacology16 (2018): 3239-3250.
  6. Baburina Y., et al. “Melatonin as a potential multitherapeutic agent”. Journal of Personalized Medicine4 (2021): 274.
  7. Posadzki PP., et al. “Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action”. BMC Medicine1 (2018): 18.
  8. Tordjman S., et al. “Melatonin: pharmacology, functions and therapeutic benefits”. Current Neuropharmacology 153 (2017): 434-443.
  9. Lim HD., et al. “Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway”. Journal of Pineal Research3 (2012): 225-237.
  10. Hosseinzadeh A., et al. “Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin”. Journal of Pineal Research 4 (2016): 411-425.
  11. Chitimus DM., et al. “Melatonin's impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease”. Biomolecules9 (2020): 1211.
  12. Bahrampour Juybari K., et al. “Melatonin potentials against viral infections including COVID-19: Current evidence and new findings”. Virus Research 287 (2020): 198108.
  13. Jin H., et al. “The role of melatonin in sarcopenia: advances and application prospects”. Experimental Gerontology 149 (2021): 111319.
  14. Han N., et al. “Melatonin alleviates d-galactose-decreased hyaluronic acid production in synovial membrane cells via Sirt1 signalling”. Cell Biochemistry and Function (2021).
  15. Stanford SC. “Recent developments in research of melatonin and its potential therapeutic applications”. British Journal of Pharmacology16 (2018): 3187-3189.
  16. Lu X., et al. “Insight into the roles of melatonin in bone tissue and bone related diseases”. International Journal of Molecular Medicine5 (2021): 82.
  17. West SK and Oosthuizen JM. “Melatonin levels are decreased in rheumatoid arthritis”. Journal of Basic Clinical Physiology and Pharmacology1 (1992): 33-40.
  18. Oskoii MA., et al. “Serum level of melatonin in patients with osteoarthritis and its relationship with 8-hydroxy-2-deoxyguanosine and vitamin D”. Journal of Research in Clinical Medicine1 (2020): 34.
  19. Jahanban-Esfahlan R., et al. “Melatonin in regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis: involvement of circadian clock genes”. British Journal of Pharmacology 16(2018): 3230-3238.
  20. Nagtegaal JE, et al. “Effects of melatonin on the quality of life in patients with delayed sleep phase syndrome”. Journal of Psychosomatic Research1 (2020): 45-50.
  21. Oh SN., et al. “Analgesic efficacy of melatonin: a meta-analysis of randomized, double-blind, placebo-controlled trials”. Journal of Clinical Medicine5 (2020): 1553.
  22. Vidor LP., et al. “Analgesic and sedative effects of melatonin in temporomandibular disorders: a double-blind, randomized, parallel-group, placebo-controlled study”. Journal of Pain and Symptom Management3 (2013): 422-432.
  23. Xie WQ., et al. “Melatonin: effects on cartilage homeostasis and therapeutic prospects in cartilage-related diseases”. Aging and Disease1 (2021): 297-307.
  24. Mehrzadi S., et al. “SARS-CoV-2 and other coronaviruses negatively influence mitochondrial quality control: beneficial effects of melatonin”. Pharmacology and Therapeutics 2224 (2021): 107825.
  25. Meng X., et al. “Dietary sources and bioactivities of melatonin”. Nutrients4 (2017): 367.
  26. Hossain FM., et al. “Physiological and pathological role of circadian hormones in osteoarthritis: dose-dependent or time-dependent?” Journal of Clinical Medicine9 (2019): 1415.
  27. Atoufi Z., et al. “Injectable PNIPAM/hyaluronic acid hydrogels contain ning multipurpose modified particles for cartilage tissue engineering: synthesis, characterization, drug release and cell culture study”. International Journal of Biological Macromolecules 139 (2019): 1168-1181.
  28. Rong J., et al. “Altered expression of the core circadian clock component PERIOD2 contributes to osteoarthritis-like changes in chondrocyte activity”. Chronobiology International3 (2019): 319-331.
  29. Hajmirzaeyian A., et al. “Melatonin attenuated the behavioral despair induced by acute neurogenic stress through blockade of N-methyl D-aspartate receptors in mice”. Heliyon 1 (2021): e05900.
  30. Zhou J., et al. “Dietary melatonin attenuates age-related changes in morphology and in levels of key proteins in globus pallidus of mouse brain”. Brain Research (2014); 1546: 1-8.
  31. Cipolla-Neto I., et al. “Melatonin, energy metabolism, and obesity: a review”. Journal of Pineal Research4 (2014): 371-381.
  32. Stacchiotti A., et al. “Impact of melatonin on skeletal muscle and exercise”. Cells2 (2020): 288.
  33. Halici M., et al. “Melatonin promotes fracture healing in the rat model”. Joint Diseases and Related Surgery 3 (2010): 172-177.
  34. Gao W., et al. “Melatonin enhances chondrogenic differentiation of human mesenchymal stem cells”. Journal of Pineal Research 1(2013): 62-70.
  35. Pei M., et al. “Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes”. Journal of Pineal Research 2 (2009): 181-187.
  36. Bazyar H., et al. “Consumption of melatonin supplement improves cardiovascular disease risk factors and anthropometric indices in type 2 diabetes mellitus patients: a double-blind, randomized, placebo-controlled trial”. Trials 1 (2021): 231.
  37. Yazar U., et al. “Electrophysiological, functional and histopathological assessments of high dose melatonin on regeneration after blunt sciatic nerve injury”. Journal of Clinical Neuroscience 72 (2020): 370-377.
  38. Guo JY., et al. “Melatonin inhibits Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes to attenuate osteoarthritis”. Oncotarget34 (2017): 55967-55983.
  39. Fu S., et al. “Circadian production of melatonin in cartilage modifies rhythmic gene expression”. Journal of Endocrinology (2019): JOE-19-0022.R2.
  40. Gao B., et al. “Melatonin rescued interleukin 1β-impaired chondrogenesis of human mesenchymal stem cells”. Stem Cell Research and Therapy1 (2018): 162.
  41. Ge J., et al. “Melatonin protects intervertebral disc from degeneration by improving cell survival and function via activation of the ERK1/2 signaling pathway”. Oxidative Medicine and Cell Longevity (2019): 2019:5120275.
  42. Huang C., et al. “Effects of melatonin on expression of bone morphogenetic protein 2 and interleukin 1beta in articular cartilage of rat with osteoarthritis”. Chinese Journal of Reparative and Reconstructive Surgery9 (2010): 1082-1087.
  43. Liu X., et al. “Melatonin mediates protective effects on inflammatory response induced by interleukin-1 beta in human mesenchymal stem cells”. Journal of Pineal Research1 (2013): 14-25.
  44. Song W., et al. “Pro-chondrogenic and immunomodulatory melatonin-loaded electrospun membranes for tendon-to-bone healing”. Journal of Materials Chemistry B42 (2019): 6564-6575.
  45. Turgut M., et al. “The effect of exogenous melatonin administration on trabecular width, ligament thickness and TGF-beta (1) expression in degenerated intervertebral disk tissue in the rat”. Journal of Clinical Neuroscience3 (2006): 357-363.
  46. Zhang Y., et al. “Melatonin prevents osteoarthritis-induced cartilage degradation via targeting microRNA-140”. Oxidative Medicine and Cell Longevity (2019): 9705929.
  47. Wu Z., et al. “Melatonin-mediated miR-526b-3p and miR-590-5p upregulation promotes chondrogenic differentiation of human mesenchymal stem cells”. Journal of Pineal Research1 (2018): e12483.
  48. Reynolds J and Dubocovich ML. “Melatonin multifaceted pharmacological actions on melatonin receptors converging to abrogate COVID-19”. Journal of Pineal Research (2021): e12732.
  49. Paulino Silva KM., et al. Chondroprotective effect of melatonin and strontium ranelate in animal model of osteoarthritis”. Heliyon 4 (2021): e06760.
  50. Nowak J and Zawilska J. “Melatonin and its physiological and therapeutic properties”. Pharmacy World and Science 20 (1998): 18-27.
  51. MacDonald IJ., et al. “Reconsidering the role of melatonin in rheumatoid arthritis”. International journal of Molecular Sciences.8 (2020): 2877.
  52. Grässel S., et al. “Osteoarthritis: novel molecular mechanisms increase our understanding of the disease pathology”. Journal of Clinical Medicine9 (2021): 1938.
  53. Isternas AF., et al. “Unintended consequences of COVID-19 safety measures on patients with chronic knee pain forced to defer joint replacement surgery”. Pain Reports6 (2020): e855.
  54. Castro da Rocha FA., et al. “Tackling osteoarthritis during COVID-19 pandemic”. Annals of the Rheumatic Diseases2 (2021): 151-153.
  55. Kammar-García A., et al. “Impact of comorbidities in Mexican SARS-COV-2-positive patients: a retrospective analysis in a national cohort”. Revista de Investigación Clínica 3 (2020): 151-158.
Citation: Ray Marks. “Melatonin and Osteoarthritis: An Overlooked Mediator?”. EC Orthopaedics 12.6 (2021): 01-09.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


June Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the June issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for upcoming Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before June 30, 2021.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to editor@ecronicon.uk