Case Report
Volume 12 Issue 7 - 2021
Severe Covid-19 is a Risk Factor for Gout Even in Hypouricaemic ICU Patients. Sign of Arousal of NLPR3 Activation?
Tim L Th A Jansen1*, Ioana Hotea1,2 and Jos LML le Noble3,4
1Department of Rheumatology, VieCuri Medical Centre, Venlo, Venlo, The Netherlands
2Department of Rheumatology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
3Department of Intensive Care, BX VieCuri Medical Centre, Venlo, Venlo, The Netherlands
4Departments of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre, AZ Maastricht, The Netherlands
*Corresponding Author: Tim L Th A Jansen, Department of Rheumatology, VieCuri Medical Centre, Venlo, Venlo, The Netherlands.
Received: May 14, 2021; Published: June 08, 2021


Severe Acute Respiratory Syndrome Corona Virus type 2 (SARS-CoV2) causes a mild to a fulminant respiratory viral infection by entering via ACE2 receptors. In some cases, the host response is upregulated to a fulminant cytokine storm or better cytokine release syndrome (CRS). In early infections with a mild course, it has been shown that increased levels of interleukin 1 beta, interleukin 1 Receptor Antagonist, interleukin 6, tumor necrosis factor alpha, interleukin 10 and soluble urokinase plasminogen activator receptor are in circulation with an increased expression of NOD-Like Receptor Pyrin domain 3 (NLRP3) [1]. Some studies indeed have shown a prompt clinical improvement with IL1 blockade [2-5]. At Intensive Care Units these SARS-CoV2-induced cases are often seen with an acute respiratory distress syndrome (ARDS) being the predominant and primary cause of death among SARS-CoV2 infected ICU patients but the pathobiological mechanism is still under debate. Here two cases are described with an acute crystal-proven gout during admission on our ICU department for COVID-19 while on hypercaloric feeding, having a low serum rate, but clearly no history of previous gout.

Keywords: Acute Respiratory Distress Syndrome; Arthritis; COVID-19; Gout


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Citation: Tim L Th A Jansen., et al. “Severe Covid-19 is a Risk Factor for Gout Even in Hypouricaemic ICU Patients. Sign of Arousal of NLPR3 Activation?”. EC Orthopaedics 12.7 (2021): 33-38.

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