1Department of Orthopedic Surgery, Christus Muguerza del Parque Hospital, Col. Centro, Chihuahua, Mexico
2ABC Medical Center, Orthopedic Division, Mexico City, Mexico
3Professor-Researcher, Faculty of Medicine and Biomedical Sciences, University Autonomous of Chihuahua, Chihuahua, Mexico
4University Anáhuac México Norte, Huixquilucan, State of Mexico, Mexico
5Faculty of Medicine and Biomedical Sciences, University Autonomous of Chihuahua, Chihuahua, Mexico
Abstract
High-energy fractures with bone loss are a true challenge for orthopedic surgeons, requiring complex reconstruction techniques and the use of bone grafts. Despite basic science advances, knowledge about the process of human bone allograft integration is limited. The aim of this case report is to document the remodel and integration process of a cortical bone allograft, until indistinguishable from the bone host in a pediatric patient with case follow-up for 8 years.
Evidence level: IV.
Keywords: Bone Loss; Fracture; Allograft; Integration; Remodel
References
- Santili Cláudio., et al. "Fraturas Da Diáfise Da Tíbia Em Crianças". Acta Ortopédica Brasileira1 (2010): 44-48.
- Bartlett Craig S., et al. "Treatment of Type II and Type III open tibia fractures in children". Journal of Orthopaedic Trauma5 (1997): 357-362.
- Berumen Edmundo., et al. "Fresh Frozen Osteochondral Allografts Reconstruction Of The Proximal Humerus, After Severe Gunshot Injury: A Case Report". EC Orthopedics2 (2015): 82-86.
- Bauer Thomas W and George F Muschler. "Bone Graft Materials". Clinical Orthopaedics and Related Research 371 (2000): 10-27.
- Ngoc Nguyen. "Basic Knowledge of Bone Grafting". Bone Grafting. Intech (2012).
- Bustos-Mora R., et al. “Inducción de membrana y trasposición de peroné ipsilateral no vascularizado en neoformación ósea postraumática. Reporte de caso” [Membrane induction and transposition of non-vascularized ipsilateral fibula in posttraumatic bone neoformation. Case report]. Acta Ortopedica Mexicana6 (2018): 366-370.
- Sutherland D and M Bostrom. "Book Reviews". Annals of the Royal College of Surgeons of England3 (2006): 333-335.
- Beer Adam J., et al. "Use of allografts in orthopaedic surgery: Safety, procurement, storage, and outcomes". Orthopaedic Journal of Sports Medicine12 (2019): 232596711989143.
- Laine Jennifer C., et al. "The management of soft tissue and bone loss in type IIIB and IIIC pediatric open tibia fractures". Journal of Pediatric Orthopaedics5 (2016): 453-458.
- Keating JF., et al. "The Management of Fractures with Bone Loss". The Journal of Bone and Joint Surgery. British Volume2 (2005): 142-150.
- Ruta David and Kagan Ozer. "Primary bone grafting in open fractures with segmental bone loss". The Journal of Hand Surgery4 (2014): 779-780.
- Fakoor Mohammad., et al. "Assessment Of Prophylactic Bone Grafting Effect On Union Of Open Tibial Fracture". Pakistan Journal of Medical Sciences1 (2012): 112-114.
- Tropet Y., et al. "One-Stage Emergency Treatment Of Open Grade IIIB Tibial Shaft Fractures With Bone Loss". Annals of Plastic Surgery2 (2001): 113-119.
- Blick S S., et al. “Early prophylactic bone grafting of high-energy tibial fractures”. Clinical Orthopaedics and Related Research 240 (1989): 21-41.
- Salgado Patrícia C., et al. "Bone Remodeling, Biomaterials And Technological Applications: Revisiting Basic Concepts". Journal of Biomaterials and Nanobiotechnology3 (2011): 318-328.
- Greenwald A Seth., et al. "Bone-Graft Substitutes: Facts, Fictions, And Applications". The Journal of Bone and Joint Surgery-American Volume2 (2001): 98-103.
- Palanisamy Jeya Venkatesh and R Balachandran. "Incorporation Of Allogenous Fibular Graft In Pediatric Humerus Following Segmental Resection". IOSR Journal of Dental and Medical Sciences4 (2016): 1-4.
- Berumen Edmundo., et al. "Tratamiento De Lesiones Osteocartilaginosas: Trasplante De Aloinjertos Osteocondrales". Ortho-Tips4 (2009): 326-338.
- Berumen, Edmundo., et al. “Repair of segmental defect of the tibia using and platelet-derived growth factors: a rat model”. Latin American Journal of Arthroscopy and Sports Traumatology6 (2010): 81-91.
- Levine Michael A. "Assessing Bone Health In Children And Adolescents". Indian Journal of Endocrinology and Metabolism2 (2012): S205-S212.
- Soucacos Panayotis N., et al. “An update on recent advances in bone regeneration”. Injury2 (2008): S1-S4.
- Bitar, I., et al. "Results Of The Incorporation Of Free Cryopreserved Non-Histocompatible Bone Allograft Vs. Non-Histocompatible Fresh Free Bone Allograft Experimental Surgery". Asociación Argentina De Ortopedia Y Traumatología2 (2000): 122-129.
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