Research Article
Volume 9 Issue 3 - 2020
Increased Receptor for Advanced Glycation End Products (RAGE) in Children with Autism
AJ Russo1*, Albert Mensah2 and Judith Bowman2
1Visiting Assistant Professor of Biology, Drew University, Madison, NJ and Research Director, Mensah Medical Center, Warrenville, Il, USA
2Mensah Medical Center, Warrenville, Il, USA
*Corresponding Author: AJ Russo, Visiting Assistant Professor of Biology, Drew University, Madison, NJ and Research Director, Mensah Medical Center, Warrenville, Il, USA.
Received: April 05, 2020; Published: April 24, 2020




Abstract

Receptor for advanced glycation end products (RAGE) is an immunoglobulin superfamily receptor that binds to HMGB1. High mobility group box 1 (HMGB1) proteins are diverse nuclear proteins that function as proinflammatory cytokines. In this study we measured RAGE in autistic children, with and without GI disease. In this study, we found RAGE significantly increased in an autistic group, particularly those with GI disease. This suggests that a HMGB1/RAGE pathway may be associated with inflammation seen in many individuals with autism.

Keywords: Receptor for Advanced Glycation End Products (RAGE); High Mobility Group Box 1 (HMGB1); Autism

References

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Citation: AJ Russo., et al. “Increased Receptor for Advanced Glycation End Products (RAGE) in Children with Autism”. EC Paediatrics 9.5 (2020): 31-34.

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