Opinion
Volume 10 Issue 5 - 2021
Rationale for Use of Prophylactic Antifungal Therapy in Pediatric Patients with Leukemia and Hematopoietic Stem Cell Transplantation
Surekha Tony1*, Tony John2 and Roshan Mevada3
1Pediatric Hematology/Oncology/BMT Unit, Department of Child Health, Sultan Qaboos University Hospital, Oman
2Jawaharlal Nehru Medical College, Belgaum, India
3Father Muller Medical College, Mangalore, India
*Corresponding Author: Surekha Tony, Pediatric Hematology/Oncology/BMT Unit, Department of Child Health, Sultan Qaboos University Hospital, Oman.
Received: April 14, 2021; Published: April 23, 2021




Abstract

Invasive fungal infections (IFIs) are an important concern in immunocompromised patients with high morbidity and mortality and treatment of these infections can be difficult once established. The significance of prevention cannot be overemphasized.

Although approaches include preventing exposure through environmental strategies (e.g. high efficient particulate air filters), preventing disease with the use of antifungal prophylaxis remains of high significance.

Keywords: Invasive Fungal Infections; Immunocompromised; Children; Antifungal Prophylaxis

References

  1. Dvorak CC., et al. “Antifungal Prophylaxis in Pediatric Hematology/Oncology: New Choices and New Data”. Pediatr Blood Cancer1 (2012): 21-26.
  2. Safdar A. “Difficulties with fungal infections in acute myelogenous leukemia patients: immune enhancement strategies”. Oncologist 12 (2007): 2-6.
  3. Steinbach WJ., et al. “Prospective Aspergillus galactomannan antigen testing in pediatric hematopoietic stem cell transplant recipients”. The Pediatric Infectious Disease Journal 7 (2007): 558-564.
  4. Burgos A., et al. “Pediatric invasive aspergillosis: a multicenter retrospective analysis of 139 contemporary cases”. Pediatrics5 (2008): e1286-1294.
  5. Dvorak C., et al. “Risks and outcomes of invasive fungal infections in pediatric patients undergoing allogeneic hematopoietic cell transplantation”. Hematopoietic Stem cell Transplantation 36 (2005): 621-629.
  6. Safdar A., et al. “Infections in 100 cord blood transplantations: Spectrum of early and late posttransplant infections in adult and pediatric patients 1996-2005”. Medicine (Baltimore) 86 (2007): 324-333.
  7. Van Burik JA., et al. “Higher risk of cytomegalovirus and aspergillus infections in recipients of T cell-depleted unrelated bone marrow: analysis of infectious complications in patients treated with T cell depletion versus immunosuppressive therapy to prevent graft-versus-host disease”. Biology of Blood and Marrow Transplantation 12 (2007): 1487-1498.
  8. Sung L., et al. “Microbiologically documented infections and infection-related mortality in children with acute myeloid leukemia”. Blood 110 (2007): 3532-3539.
  9. Sung L., et al. “Infections and association with different intensity of chemotherapy in children with acute myeloid leukemia”. Cancer 115 (2009): 1100-1108.
  10. Afzal S., et al. “Risk factors for infection-related outcomes during induction therapy for childhood acute lymphoblastic leukemia”. The Pediatric Infectious Disease Journal 28 (2009): 1064-1068.
Citation: Surekha Tony., et al. “Rationale for Use of Prophylactic Antifungal Therapy in Pediatric Patients with Leukemia and Hematopoietic Stem Cell Transplantation”. EC Paediatrics 10.5 (2021): 37-39.

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