Research Article
Volume 10 Issue 7 - 2021
Is Thrombocytopenia a Novel Risk Factor for Cardiac Complications in Kawasaki Disease? Findings to the Mexican Network of Kawasaki Disease
José de Jesús Coria-Lorenzo1,2*, Rodolfo Norberto Jiménez-Juárez3, Sandra Enciso4, Norberto Sotelo-Cruz5, Daniel Ramírez-Bouchand6, Omar Enríquez-Cisneros7, José Luis Díaz-Luna8, Jaime Julio Unda-Gómez9, Roselia Ramírez-Rivera10, Lucila Martínez-Medina11, Alejandro Díaz-Toquero12, Michel Gutiérrez-Ceniceros13, Alfonso Reyes-López14 and Víctor Cruz-Olivos15
1Hospital Epidemiology Department, Children´s, Hospital of Mexico Federico Gómez, Mexico
2Research and Teaching, General Hospital ISSSTE Toluca, Mexico
3Pediatric Department, Infectious Diseases Hospital, Medical Center La Raza-IMSS, Mexico
4Laboratory Research on Nephrology and bone mineral metabolism, Children´s Hospital of Mexico Federico Gómez, Mexico
5Medicine Department, Sonora State University, Mexico
6Children´s and Woman Hospital, San Luis Potosí, Mexico
7West General Hospital, Guadalajara Jalisco, Mexico
8Hospital of Xalapa, Veracruz, Mexico
9Medical Center Iron Door, Zapopan, Jalisco, Mexico
10Hospital Specialties Child and Woman, Querétaro, Mexico
11Century Hospital Miguel Hidalgo, Aguascalientes, Mexico
12MEDICA KIDS Private Pediatrics, Mexico
13Unit of Research in Neurodevelopment, Hospital of Mexico Federico Gómez, Mexico
14Center of Economic and Social Studies, Hospital of Mexico Federico Gómez, Mexico
15Pediatric Internal Medicine Department, General Hospital “Gaudencio Gonzalez Garza”, Medical Center La Raza-IMSS, Mexico
*Corresponding Author: José de Jesús Coria Lorenzo, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
Received: May 24, 2021; Published: June 17, 2021




Abstract

Background: Kawasaki disease is a systemic inflammatory disease, usually self-limited, characterized by fever and manifestations of acute inflammation. Complications such as coronary artery aneurysms, heart failure and acute myocardial infarction, among others, lead to significant morbidity and mortality. Is maybe the most common acquired heart disease cause in children. The aim of this study was to evaluated clinical features and epidemiology as potential risk factors for cardiac complications.

Methods: Multicenter, retrospective cross-sectional study was conducted in children with a discharge diagnosis of Kawasaki disease and almost one echocardiographic study. We made a bivariate analysis, then it fit a logistic regression model in order to assess the risk factors for cardiac complications, ectasias or aneurysms coronary.

Results: One hundred and eighty-two medical records were reviewed, 3 were excluded because no echocardiogram was performed, 179 records were analyzed, 68% had a complete presentation of Kawasaki. Cardiac manifestations occurred in 47% cases, 32.4% presented ectasia and 27.4% coronary aneurysms. Fever lasting more than 10 days’ thrombocytopenia and spring and autumn seasons were identified as independent predictors for cardiac abnormalities in our study population.

Conclusion: Thrombocytopenia is a novel risk factor for aneurysms in KD in our Mexican children.

Keywords: Kawasaki Disease; Thrombocytopenia; Coronary Artery Aneurysm; Vasculitis; IVIG

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Citation: José de Jesús Coria Lorenzo., et al. “Is Thrombocytopenia a Novel Risk Factor for Cardiac Complications in Kawasaki Disease? Findings to the Mexican Network of Kawasaki Disease”. EC Paediatrics 10.7 (2021): 26-32.

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