Research Article
Volume 10 Issue 8 - 2021
Impact of Collagen Disorders on the Formation of Gastroduodenal Pathology in Children and Adolescents
Inna Yakovleva* and Ludmila Bogmat
Department of Cardiorheumatology, Institute for Children and Adolescents Health Care at the National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine
*Corresponding Author: Inna Yakovleva, Department of Cardiorheumatology, Institute for Children and Adolescents Health Care at the National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine.
Received: June 19, 2021; Published: July 26, 2021


Introduction: Connective tissue pathology is a base of formation chronic diseases in children and associated with an expressed immunodeficiency. Many connective tissue disorders (CTD) carry high risks for life-threatening heart and blood vessel conditions. Gastrointestinal tract, as it contents a lot of collagen, may also be impacted with the subsequent development of inflammatory-destructive damages.

This study aimed to evaluate the significance of collagen level content of the gastroduodenal tract in the formation of peculiarities of gastroduodenal pathology in adolescents.

Materials and Methods: Inflammatory-destructive diseases of gastroduodenal tract were studied in 155 adolescents 11 to 18 years of age. The traits of the CTD, including the Marfan syndrome, were determined relying on the Ghent criteria. CTD were revealed in 90 adolescents. 65 peers without CTD were included in the comparison group. Collagens content in the lamina propria of gastric-duodenum mucosa was evaluated by immunohistochemistry with using monoclonal antibodies of collagen 1, 3, 4, 5 types. Biopsy samples were studied in luminescent microscope with using light filters. Complex evaluation of connective tissue parameters was carried out using the system correlation analysis.

Results: Gastrointestinal involvement against the background of the CTD is characterized primarily by motility disorders, including gastroesophageal reflux disease, reflux-gastritis (77%; comparison group - 29%, p < 0,001) and a reduced level of interstitial collagens. The average immunofluorescence intensity of collagen types 1 and 3 in patients with CTD was significantly lower (p < 0,01). The connective tissue matrix of the mucosa is characterized by structural transformation of collagen fibrils (wrong orientation, focal sclerosis, immaturity). It is accompanied by decrease in a mucosa functional ability with development of the valve-sphincter failure. The form of mucosal lesions is a chronic non-atrophic gastritis with simultaneous inflammation in the antral and fundal parts. Duodenal ulcer was identified rarely (10,0%; comparison group - 33,8%; p < 0,035), and it was accompanied by detection of Helicobacter pylori.

Conclusion: Thus, CTD in adolescents is characterized by low level of interstitial collagens in gastric-duodenal mucosa, and accompanied by structural transformation of collagen fibrils, that is the basis of formation of motility disorders with the subsequent development of gastritis and esophagitis against the background of reflux. The work provides grounds for employing rehabilitation measures connected with a prevention of reflux disease and development destructive lesions in children and adolescents with CTD.


Keywords: Children and Adolescents; Gastroduodenal Pathology; Connective Tissue Dysplasia; Collagen; Reflux


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Citation: Inna Yakovleva and Ludmila Bogmat. “Impact of Collagen Disorders on the Formation of Gastroduodenal Pathology in Children and Adolescents”. EC Paediatrics 10.8 (2021): 19-29.

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