Research Article
Volume 10 Issue 10 - 2021
Evolutionary Aspects of Newborns Under 1500g Treated with Fluoroquinolones in Libreville, Gabon
Kuissi Kamgaing Eliane1,2*, S Minto'o Rogombe1, R Koumba Maniaga1,2, A Lembet Mikolo1,2, E Mintsa Mi Kama1,2, I Busugu Bu Mbadinga1,2 and S Ategbo1,2
1Department of Pediatrics, University of Health Sciences, BP, Libreville, Gabon
2Children Pole, Mother-Child Hospital-University Center Jeanne Ebori Foundation of Libreville, BP, Libreville, Gabon
*Corresponding Author: Kuissi Kamgaing Eliane, Professor, Department of Pediatrics, University of Health Sciences, BP, Libreville, Gabon.
Received: September 06, 2021; Published: September 18, 2021




Abstract

Introduction: The resistance of germs responsible for neonatal infections sometimes requires the use of fluoroquinolones that are not indicated at this age. Our goal was to assess the short- and medium-term fate of newborns under 1500g treated with fluoroquinolone in Libreville.

Methodology: Case control study, over a period of 3 years (January 2015 - December 2018). The cases consisted of newborns under 1500g treated for neonatal infection with fluoroquinolones. Controls were newborns under 1500g treated for neonatal infection with other antibiotic families. The parameters studied were urea, creatinine, blood glucose of cases at Day0, Day10 and Day30 post-treatment. We compared anthropometric parameters and motor acquisition at 3, 6 and 12 months of the two groups.

Results: In the fluoroquinolones group, sepsis was the most observed localization (60%) and E. coli the most found germ (28%). The average time to the introduction of fluoroquinolones was 15d ± 7d. The most widely used molecule was Ciprofloxacin (68%). The most observed side effect was hypoglycaemia (28%) and an increase in serum creatinine (p = 0.006) and uremia (p = 0.0013) was observed on Day10 post-treatment. We did not observe any musculoskeletal manifestations. The evolution of anthropometric parameters and motor development was comparable in the 2 groups.

Conclusion: Fluoroquinolones motivated by the consideration of benefit/risk are well tolerated in newborns under 1500g.

Keywords: Low Weight Newborn; Fluoroquinolones; Libreville-Gabon

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Citation: Kuissi Kamgaing Elianel., et al. “Evolutionary Aspects of Newborns Under 1500g Treated with Fluoroquinolones in Libreville, Gabon”. EC Paediatrics 10.10 (2021): 55-62.

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