Research Article
Volume 10 Issue 10 - 2021
Impact of Early Nutrition on Postnatal Growth and Neurodevelopmental Outcome in Very Low Birth Weight Infants in a Tertiary Care NICU in India
Ashwin S Pradhu, Jayasree Chandramati and Sasidharan Ponthenkandath*
Department of Pediatrics, UCR School of Medicine, USA
*Corresponding Author: Sasidharan Ponthenkandath, Department of Pediatrics, UCR School of Medicine, USA.
Received: September 07, 2021; Published: September 22, 2021




Abstract

Background: Postnatal growth restriction has become a major concern as survival rate of extremely low birth weight infants increased. In developing countries many of these infants are born growth restricted compounding to extrauterine growth restriction. Our aim was to study the impact of early nutrition on post-natal growth and short-term neurodevelopmental outcome of infants born under 34 weeks gestation.

Methods: In this retrospective study, we analyzed the caloric and protein intake during the first 14 days of life in preterm infants under 34 weeks GA (n = 37) and their relation to extrauterine growth restriction (EUGR). We developed a new EUGR growth curve and classified infants into mild, moderate, and severe EUGR. Mean BW and GA were 1380 ± 349 grams and 31 ± 2.62 weeks, respectively. Neurodevelopmental assessments were performed at 18 months corrected postnatal age.

Results: The incidence of EUGR was 100% in this cohort based on Olsen growth curve and 86% in the Fenton growth curve. Moderate to severe EUGR group had lower BW, received less calories during the first 14 days of age, had longer hospital stay, and worse neurodevelopmental outcome at 18 months compared to mild EUGR group. There were no differences in gestational age at birth, protein intake, incidence of sepsis or RDS between the groups.

Conclusion: In this single center study we found that nutrition during the first 2 weeks of postnatal age has direct effect on the incidence of EUGR and impacts long-term outcome of preterm infants.

Keywords: Preterm Infants; EUGR; Outcome; Early Nutrition

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Citation: Sasidharan Ponthenkandath., et al. “Impact of Early Nutrition on Postnatal Growth and Neurodevelopmental Outcome in Very Low Birth Weight Infants in a Tertiary Care NICU in India”. EC Paediatrics 10.10 (2021): 63-69.

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