Research Article
Volume 10 Issue 12 - 2021
Search of New Autoimmune Marker in Diagnostic Diabetes Mellitus Type 1
Osadchuk Z1,2, Akopyan H1,2, Nataliya Kitsera1,2*, Kovaliv I1,2 and Danylevych N1,2
1SI “Institute of Hereditary Pathology of Medical Sciences of Ukraine”, Lviv, U
2Lviv Regional Endocrinological Centrum, Lviv, Ukraine
*Corresponding Author: Nataliya Kitsera, Epidemiology of Birth Defects and Hereditary Pathology, Institute of Hereditary Pathology of Medical Sciences of Ukraine, Lviv, Ukraine.
Received: October 05, 2021; Published: November 18, 2021




Abstract

Background: For diabetes mellitus is characterized by increased immunogenicity, which triggers the development of autoimmune processes and leads to the production of various autoantibodies. In order to find a new marker of autoimmune accumulation in type I diabetes, using immunoassay method, the level of antibodies to the protein eEF1A1 in blood of patients with type 1 diabetes mellitus and those in the control group was performed.

Results: The main group consisted of 52 patients with type I diabetes who were hospitalized in the Lviv Regional Endocrinology Сentrum (West Ukraine) from 2018 to 2019 years. The control group included 40 people of the appropriate age and sex, where the family denied the presence of diabetes. The gender and age structure of the study group was different: the group consisted of 32 (61.5%) women and 20 (38.5%) males.

Clinical examination and analysis of data from medical records shows that in the majority of patients with type 1 diabetes, endocrinologists diagnosed serious complications: polyneuropathy - in 32 (61,5%) patients, retinopathy - in 28 (53,8%) and nephropathy - in 14 (26,9%) cases. Naturally, many of the 34 (65,4%) patients from the main group of doctors found a combination of these complications, which depended on the severity of their course of diabetes.Diagnosed significantly higher rates of cardiovascular events 18 (34.6%), ophthalmic 28 (53.8%) and neurological pathologies 32 (61.5%) in the main group were considered to be the domination of complications of diabetes in patients in contrast to the control group.

Antibodies to the eEF1A1 protein were absent in 35 (67.3%) patients with type I diabetes and in 39 (97.5%) subjects. Low titers of autoantibodies (from 1:20 to 1:160) to the eEF1A1 protein were observed in 5 (9.6%) patients with type I diabetes and in 1 (2.5%) of the control group. In contrast to individuals without diabetes mellitus, diagnostically significant antibodies to eEF1A1 protein in higher concentrations (from 1: 320 to 1: 640) were recorded in 12 patients (23.1%) with type I diabetes from the main group, which differed significantly (p < 0.05) from data from the control group.

Conclusion The level of antibodies to the protein eEF1A1 in blood patients with type I diabetes possible can consider as a new autoimmune marker in diagnostic diabetes mellitus type 1.

Keywords: Diabetes Mellitus Type 1; New Autoimmune Marker; Ukraine

References

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Citation: Nataliya Kitsera., et al. “Search of New Autoimmune Marker in Diagnostic Diabetes Mellitus Type 1”. EC Paediatrics 10.11 (2021): 05-09.

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