Research Article
Volume 11 Issue 2 - 2022
Mortality and Morbidity Outcomes in Infants Born Less than 28 Weeks Related to Surfactant Doses
Saima Asghar*, Ahmad Abdullah and Khalil Ur Rehman
Department of Neonatology, Mediclinic Welcare Hospital, United Arab Emirates
*Corresponding Author: Saima Asghar, Department of Neonatology, Mediclinic Welcare Hospital, United Arab Emirates.
Received: December 16, 2021; Published: January 31, 2022


Objective: To identify characteristics and outcomes of infants who received multiple doses of surfactant vs those who received one dose.

Methodology: In this retrospective study, we included premature neonates admitted to NICUs in the Mediclinic welcare hospital Dubai from May 2017 till May 2020. Patients were divided into two groups: single dose, and multiple doses. The primary outcome was a composite of death rate or any of the major morbidities, including severe neurological injury, bronchopulmonary dysplasia, or ≥ stage 3 retinopathy of prematurity.

Results: In our study total 127 neonates were enrolled, 35.4% received multiple doses of surfactant. Mean age was 2.6 ± 1.7 hours at time of first dose and 5.6 ± 2.8 hours at time of repeat surfactant dose. Total 34 neonates expired, 70.6% received single dose and 29.7% received multiple doses. Neurological injury was present in 65 neonates, 69.2% received single dose and 30.8% received multiple doses. Broncho pulmonary dysplasia was present in 68 patients, 70.6% received single dose and 29.4% received multiple doses. Third stage of retinopathy was present in 20 patients, all received only single dose of surfactant. Mean duration of ventilation in single dose neonates was 38.6±19.6 hours and 18.2±1.8 hours in those who received repeat dose. Mean duration of bubble CPAP was 72.6±16.1 hours in neonates receiving single dose of surfactant and 50±8.2 hours in those receiving multiple doses of surfactant.

Conclusion: Multiple doses of surfactant was associated with good neonatal outcomes.

Keywords: Respiratory Distress Syndrome: Surfactant Therapy, Multiple Doses, Death Rate


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Citation: Saima Asghar., et al. “Mortality and Morbidity Outcomes in Infants Born Less than 28 Weeks Related to Surfactant Doses”. EC Paediatrics 11.2 (2022): 103-110.

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