Research Article
Volume 11 Issue 4 - 2022
Safety and Efficacy of Intravenous Lipid Emulsion Containing Soyabean Oil, Medium Chain Triglycerides, Olive Oil, and Fish Oil (SMOF Lipid) vs. Conventional Lipid Emulsion: A Single-Center, Double Blind Randomized Controlled Trial in Neonates Requiring Parenteral Nutrition
Jay Shah1*, Shekhar Biswas2, Anirudh Ghai3 and Vishal Jain4
1DNB, Department of Pediatrics, Jaipur Golden Hospital, Rohini, New Delhi, India
2Senior Consultant, Department of Pediatrics, Jaipur Golden Hospital, Rohini, New Delhi, India
3Senior Consultant and HOD, Department of Pediatrics, Jaipur Golden Hospital, Rohini, New Delhi, India
4Neonatologist, Jaipur Golden Hospital, Rohini, New Delhi, India
*Corresponding Author: Jay Shah, DNB, Department of Pediatrics, Jaipur Golden Hospital, Rohini, New Delhi and Assistant Professor, Department of Pediatrics, Pramukhswami Medical College, Bhaikaka University, Karamsad, Gujarat, India.
Received: February 17, 2022; Published: March 11, 2022




Abstract

Background: Intravenous lipid emulsions are an integral part of the PN in neonates. Because of their high content of PUFAs and limited content of α­tocopherol, they deplete antioxidant defences. The need for more appropriate lipid emulsions in neonatal care is well recognized.

Aims and Objectives: To evaluate the safety and effects of two different intravenous lipid emulsion in neonates requiring total parenteral nutrition.

Materials and Methods This study was a single center, double blind randomized controlled trial conducted in NICU of a tertiary care hospital, from December 2017 to November 2018. Eighty premature newborns of < 34 weeks gestational age were randomized equally to two groups - SMOF lipid and Intralipid. Anthropometric measurements and biochemical variables including serum triglycerides, total and direct bilirubin, SGOT, SGPT, GGT and BUN were assessed in laboratory at 7 and 14 days.

Results: The two groups were comparable at baseline with regards to gestational age, weight, length, and head circumference. Comparison between SMOF group and IL group for anthropometric parameters, Duration of NICU stay and number of days taken to reach birth weight showed that both groups were comparable (p > 0.05). Triglycerides, SGOT, SGPT, GGT, BUN were significantly higher in IL group than SMOF group at 7 (p < 0.05) and 14 (p < 0.05) days.

Conclusion: SMOF is safe and well tolerated in preterm neonates requiring parenteral nutritionand using of SMOF lipid might be advantageous with regard to better biochemical parameters compared to conventional Intralipid.

 

Keywords: Parenteral Nutrition; Preterm; SMOF Lipid; Intralipid

References

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Citation: Jay Shah., et al. “Safety and Efficacy of Intravenous Lipid Emulsion Containing Soyabean Oil, Medium Chain Triglycerides, Olive Oil, and Fish Oil (SMOF Lipid) vs. Conventional Lipid Emulsion: A Single-Center, Double Blind Randomized Controlled Trial in Neonates Requiring Parenteral Nutrition”. EC Paediatrics 11.4 (2022): 13-22.

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