Research Article
Volume 11 Issue 4 - 2022
Malondialdehyde and Haptoglobin among Sickle Cell Disease Children in Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria
Osaro Erhabor1*, Nma Muhammed Jiya2, Murtala Bello Abubakar3 and Sadiya Usman1
1Department of Haematology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria
2Department of Paediatrics, Usmanu Danfodiyo University, Teaching Hospital Sokoto, Sokoto, Nigeria
3Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria
4Medical Laboratory Science Council of Nigeria, Abuja
*Corresponding Author: Osaro Erhabor, Department of Haematology, School of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
Received: February 21,2022; Published: March 31, 2022




Abstract

Objectives: Sickle Cell Disease (SCD) is global public health problem. The disease is characterized by free radical associated oxidative stress. This study investigated the malondialdehyde (MDA) and haptoglobin (Hp) levels among children with SCD in Sokoto, Nigeria.

Methods: This study investigated the serum malondialdehyde (MDA) and haptoglobin (Hp) levels among 60 children with SCD. The subjects for this study were categorized into two groups; those in the steady state A (n = 30) and those presenting with vaso- occlusive crisis (VOC) B (n = 30). Twenty-two age-matched non- SCA children served as control (C).

Results: The Hp was significantly lower among the sickle cells subjects compared to controls (p = 0.00) while the MDA level was significantly higher among the SCD subjects compared to controls (p = 0.00). The result showed a statistically significant difference between the MDA and Hp levels of group A versus C (p = 0.000 and 0.011) and B versus C groups (p = 0.000). We did not observe a statistically significant difference between A versus B group (p > 0.05). The effect of age on the MDA and Hp among sickle cell disease children was compared. Age did not have a statistically significant effect on the MDA and Hp levels of the sickle cell subjects (p=0.191 and 0.520) respectively. There was no statistically significant difference in the MDA and Haptoglobin level among sickle cell disease subjects based on gender (p = 0.948 and 0.423) respectively. Ethnicity, maternal occupational group and income level had no statistically significant effect on the MDA and Haptoglobin level among sickle cell disease subjects (p > 0.05).

Conclusion: The finding from this study indicates that SCD subjects tend to have lower values of Hp and higher values of MDA compared to controls. Strategies using antioxidants and therapeutic haptoglobin to protect against plasma lipid oxidation by cell-free haemoglobin may reduce the deleterious effects of lysis-associated cell-free Hb seen in SCD.

 

Keywords: Malondialdehyde; Haptoglobin; Children; SCD; UDUTH; Sokoto; Nigeria

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Citation: Osaro Erhabor., et al. “Malondialdehyde and Haptoglobin among Sickle Cell Disease Children in Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria”. EC Paediatrics 11.4 (2022): 105-116.

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