Research Article
Volume 10 Issue 4 - 2021
Clinical Features Effecting the Diagnostic Yield of Transthoracic Needle Aspiration Biopsy in Primary Malignant Lung Tumors
Halil Yanardag1, Cuneyt Tetikkurt2*, Muammer Bilir1, Seza Tetikkurt3 and Emre Yanardag4
1Professor, Department of Internal Medicine Medicine, Cerrahpasa Medical Faculty, Istanbul Cerrahpasa University, Istanbul, Turkey
2Professor, Department of Pulmonary Medicine, Cerrahpasa Medical Faculty, Istanbul Cerrahpasa University, Istanbul, Turkey
3Professor, Department of Pathology, Demiroglu Bilim University Medical Faculty, Istanbul, Turkey
4Resident, Department of Internal Medicine, Haseki State Hospital, Istanbul, Turkey
*Corresponding Author: Cuneyt Tetikkurt, Professor, Department of Pulmonary Medicine, Cerrahpasa Medical Faculty, Istanbul Cerrahpasa University, Istanbul, Turkey.
Received: October 01, 2020; Published: March 31, 2021




Abstract

The aim of this study was to determine the clinical and radiologic features that may predict the diagnostic yield of transthoracic needle aspiration biopsy in primary lung tumors. A retrospective evaluation for the final results of 284 patients was conducted to evaluate the clinical and the radiological manifestations associated with the diagnostic sensitivity and specificity of the transthoracic needle biopsy for primary pulmonary malignant tumors. Of these patients 246 had focal and 38 had diffuse lung diseases. All patients had chest x-ray and thorax CT. The patients underwent a transthoracic fine-needle aspiration biopsy under computed tomography guidance. The mean diameter of the pulmonary nodules was 24.2 ± 11.4 mm. Histopathological accuracy were obtained in 252 (88.7%) patients. Minor complications developed in %11.2 while pneumothorax occured in 6.4% of the individuals. Sensitivity and specificity of the TNA biopsy was noted to be 87.1% and 76.2%, respectively. The diagnostic accuracy of the TNA biopsy was 67.6% for primary lung tumors. Clinical and imaging manifestations were assessed to predict the diagnostic yield of the TNA biopsy for primary malignant lung tumors.

Certain radiologic features of the chest x-ray, thorax CT and PET/CT imaging were found to be extremely useful as the initial enterprises for predicting the sensitivity and specificity of the transthoracic needle aspiration biopsy for primary malignant lung tumors. Clinical manifestations revealed a low correlation relevant to the diagnostic yield of the TNAB. Imaging findings showed the highest correlation with the diagnostic accuracy of the TNA biopsy. Collaboration of the clinical and imaging results significantly increased the predictive diagnostic rendement of the TNA biopsy in regard to the sensitivity and specificity that is the hallmark to obtain adequate lung tissue compatible with the final diagnosis.

Keywords: Lung Cancer; Pulmonary Nodule; Transthoracic Needle Aspiration Biopsy; TNAB; Malignant Pulmonary Nodule

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Citation: Cuneyt Tetikkurt., et al. “Clinical Features Effecting the Diagnostic Yield of Transthoracic Needle Aspiration Biopsy in Primary Malignant Lung Tumors”. EC Pulmonology and Respiratory Medicine 10.4 (2021): 55-64.

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