Research Article
Volume 6 Issue 7 - 2021
Effects of Calcium Supplementation on the Histology of the Cardiac Myocytes of Albino Wistar Rats
Hope Avwerhosuo Ugbero Odogun1*, Ighoyinvwin Peter Odogun2 and Olufunke Omolola Arishe1
1Department of Physiology, University of Benin, Nigeria
2Department of Microbiology, Near East University, Cyprus
*Corresponding Author: Hope Avwerhosuo Ugbero Odogun, Department of Physiology, University of Benin, Benin City, Edo State, Nigeria.
Received: April 24, 2021; Published: June 25, 2021




Abstract

We studied the effects of calcium supplementation on cardiac myocytes of albino wistar rats. A total of 20 albino wistar rats were purchased and acclimatized for 2 weeks and were served regular rat food and drank tap water ad libitum. They were then randomly assigned to four groups of five animals each. Group A (control) received a placebo; Group B received a low dose (7.69 mg/kg) of calcium supplements; Group C received a moderate dose (15.38 mg/kg) of calcium supplements; Group D received a high dose (23.07 mg/kg) of calcium supplements. Calcium supplements were administered for 28 consecutive days after which the animals were euthanized under chloroform anesthesia and heart was removed for histological processing and microscopic examination. Blood samples were also collected for estimation of serum calcium concentration. Results obtained showed no difference in the serum calcium concentrations amongst the groups. The histology of the heart showed normal histology in control and low dose groups and degenerative changes in the moderate and high dose groups. It was thus concluded that calcium supplementation in moderate and high doses may lead to degeneration of the cardiac myocytes.

 

Keywords: Calcium Supplementation; Cardiac Myocytes; Degeneration; Myocardial Infarction; Apoptosis; Histology

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Citation: Hope Avwerhosuo Ugbero Odogun., et al. “Effects of Calcium Supplementation on the Histology of the Cardiac Myocytes of Albino Wistar Rats”. EC Veterinary Science 6.7 (2021): 59-70.

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