Research Article
Volume 6 Issue 7 - 2021
Toxicity of Cypermethrin (Pyrethroid Insecticide) in Female Guinea Pig (Cavia porcellus)
Ngaleu Njieudeu Claude Cédric1, Vemo Bertin Narcisse2*, Guiekep Nounamo Arthénice Jemima3, Menkem Brice1, Boufack Judith Laure1, Yidjeu Nana Aristide Ferry1, Dongmo Nguedia Arius Bauland1 and Kenfack Augustave1
1Laboratory of Animal Physiology and Health, Department of Zootechnics, Faculty of Agronomy and Agricultural Sciences, University of Dschang, Dschang, Cameroon
2Department of Animal Science, Faculty of Agriculture and Veterinary Medecine, University of Buea, Buea, Cameroon
3Department of Animal Production Technology, College of Technology, University of Bamenda, Bambili, Cameroon
*Corresponding Author: Vemo Bertin Narcisse, Department of Animal Science, Faculty of Agriculture and Veterinary Medecine, University of Buea, Cameroon.
Received: June 09, 2021; Published: June 26, 2021


This study aimed at evaluating the toxicity of Cypermethrin (Pyrethroid insecticide) in female Guinea pig after 60 days. For this purpose, 40 adult female guinea pigs with an average weight of 417 ± 19.21g were randomly allocated into four groups of 10 animals each. All animals were orally treated. T0 served as the control and received distilled water, while the three other groups T1, T2 and T3 were respectively given 92, 137.5 and 275 mg/kg of body weight (bw) of cypermethrin. The studied parameters included the blood concentration of estradiol, ovary and uterus menstruation, the weight and volume of kidney and liver, indicators of the renal (creatinine and urea) and hepatic (ASAT, ALAT, proteins, cholesterol, albumin, globulin) functions and the markers of oxidative stress (Superoxide dismutase, Catalase, total peroxidases, Malondialdehyde, and tissue proteins). The malondialdehyde concentration and the activities of superoxide dismutase, catalase and total peroxidases increased significantly (p < 0.05) in animals exposed to 137.5 and 275 mg/kg bw of cypermethrin compared to the control. The levels of ASAT, ALAT, creatinine and urea were significantly (p < 0.05) higher in cypermethrin-treated guinea pigs compared to the control. Meanwhile, the reverse was observed for the levels of proteins, cholesterol and globulin. The weights of the liver, kidneys, ovaries and uterus were comparable (p > 0.05) amongst treatments. The estradiol concentration significantly (p < 0.05) decreased in groups receiving 137.5 and 275 mg/kg bw of the insecticide with the reference to the control. Hence, cypermethrin has shown to be toxic in female guinea pigs by inducing oxidative stress and causing perturbations on the renal, hepatic and reproductive functions.

Keywords: Cypermethrin; Female Guinea Pig; Oxidative Stress; Reproduction; Toxicity


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Citation: Vemo Bertin Narcisse., et al. “Toxicity of Cypermethrin (Pyrethroid Insecticide) in Female Guinea Pig (Cavia porcellus)”. EC Veterinary Science 6.7 (2021): 89-97.

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