Dr Katarina Davalieva is a senior researcher and since 2015, Head of the Proteomics Department at the Research Center for Genetic Engineering and Biotechnology "Georgi D. Efremov", Macedonian Academy of Sciences and Arts, Skopje, Macedonia. Dr. Katarina Davalieva received her Ph.D. in molecular biotechnology from the Faculty of Technology, University “Ss. Cyril and Methodius” Skopje, Republic of Macedonia in 2009. Her doctoral work was concentrated on creation of genetically modified thermostable polymerases with improved characteristics for application as molecular biology tools. From 2010, she became interested in discovering potential biomarkers for disease detection and diagnosis, by utilizing proteomics techniques. She has been on several short term trainings in 2-dimensional gel electrophoresis and DIGE (Institute Cochin, Paris, France and GE Healthcare training courses, Munich, Germany), protein identification by peptide mass fingerprinting (Vienna University of Technology, Institute of Chemical Technologies and Analytics, Vienna, Austria), Label-free quantitative proteomics (Quantitative Proteomics and Metabolomics Center, Department of Biological Sciences, Columbia University, NY, USA and Waters MS Technologies Centre, Wilmslow, UK), bioinformatics (ICGEB, Trieste, Italy), etc. Currently, her research is focused on protein expression profiling of complex diseases/conditions such as cancer, male infertility and neuropsychiatric disorders. The main aim of this research is elucidation of the disease mechanisms through whole proteome comparison of diseased and healthy tissues and search for non-invasive screening/diagnostic biomarkers through proteomics analysis of body fluids. The Department for Proteomics utilises label-free shotgun profiling with nano-LC-MS/MS and 2-D DIGE/MALDI-TOF. Katarina’s most recent work focuses on identification of urinary proteins that can be used as noninvasive diagnostics biomarkers for urogenital cancers such as kidney, bladder and prostate cancer. More specifically, it aims to evaluate the potential of the limited set of urinary proteins which show the highest specificity to be used as diagnostic markers of prostate cancer.
Katarina Davalieva Research Interests are Molecular Biotechnology, Genetic Engineering, Clinical proteomics – biomarkers in diseases, Cancer Biology, Mass spectrometry, Liquid Chromatography, Bioinformatics.