Dr. Nikhil Jain has an experience of more than 14 years in the field of Bioinformatics, Biochemistry and Structural biology gained expertise in wide range of techniques. He has been acting as a reviewer of numerous research articles in the field of Biological sciences. He has also obtained Junior and Senior research fellowship from CSIR, India. Dr. Jain has an excellent track record of publishing many research articles in several reputed journals like Nucleic acid research, Journal of Biological chemistry and PLOS genetics. His current work in Baylor college of medicine involved understanding the process of ribosome biogenesis in prokaryotes. Using a combination of bioinformatics, biochemistry and structural biology, he characterized a ribosome assembly factor along with its functional relevance in ribosome assembly. Later on, he characterized a functional intermediate in ribosome assembly pathway. His pioneer worked identified several important aspects of ribosome assembly by studying ribosomal RNAs in assembly intermediates. He uncovered assembly factor’s function in ribosome biogenesis. He has been actively working to characterize intermediates involved in ribosome assembly using biochemistry and structural biology. Using bioinformatics, he is also trying to understand diverse ribosome assembly pathways in whole microbial world. During his PhD at IIT Kanpur in India, he worked toward understanding function and GTP hydrolysis mechanism of GTPase which act as molecular switches for diverse cellular functions. He discovered a hidden ATPase domain in one of the protein thought to be only GTPase. Using structural analysis, he identified molecular hinge in the form of salt bridge between two domains of a protein and discovered its functional interaction with ribosome. His future goal is to work toward developing drugs against multidrug resistant infectious bugs.
Nikhil Jain's Research interes are Structural biology, Bioinformatics, Proteomics, Enzyme Kinetics, Molecular biology, RNA, GTPases, Multidrug resistance, Ribosome, high throughput drug screening, Chemical probing.