Pror. Victor Tsetlin has an experience of several decades in the field of Peptide chemistry, Structural biology, Neurochemistry, Neurobiology, Proteomics and Bioinformatics. For over 10 years he was a member of the Advisory Board for FEBS. J. and at present has the same duty at Biochem.J. He has been acting as a reviewer of numerous research articles in the field of biological sciences for such journals as FEBS Lett., Biochemistry, J.Neurochem., Toxicon and Sci.Rep. He was a visiting scientist at the Imperial College (London), Institute of Protein Research(Osaka), and Free University (Berlin) where he worked as a Laureate of Humboldt Prize (Germany). Prof. Tsetlin has an excellent track record of publishing many research articles in such prestigious journals as PNAS, Neuron, Nat.Struct. Mol. Biol., Journal of Biological Chemistry, PLOS One and PloS Biology, Neuropharmacology and Marine Drugs. His current work in Moscow at the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (Russian Academy of Sciences) is devoted to different classes of ion channels, especially nicotinic receptors and other Cys-loop receptors. The lab led by Victor Tsetlin is one of the leading in the world discovering novel neurotoxic proteins and using them as tools in receptor research. By combining the X-ray structures for toxin complexes, novel computational programs and a combination of functional tests (radioligand analysis, electrophysiology and fluorescence imaging) they designed and synthesized novel α-conotoxins with the extremely high affinity for the neuronal α7 nicotinic acetylcholine receptor. In the proteomic studies of diverse animal venoms, currently performed at his department, several novel structural types of receptor ligands were discovered, some of them being at preclinical studies as potential drugs.
Prof. Victor Tsetlin research interests are Structural biology, Neurochemistry, Neurobiology, Bioinformatics, Proteomics, Molecular biology, Ligand-gated ion channels , Drug design.