Dr. Xujing Wang received her PhD in Theoretical physics, and postdoctoral training in biophysics. She then held positions of assistant, and then associate professor at the Medical College of Wisconsin (MCW) from 2001-2008; and associate professor of physics at the University of Alabama at Birmingham (UAB) 2008-2013. Currently she directs the systems biology core for the National Heart Lung and Blood Institute (NHLBI). At MCW she was an investigator of the Max McGee National Research Center for Juvenile Diabetes and led the bioinformatics sector. At UAB she was an investigator of the Comprehensive Diabetes Center.
Currently, Dr. Wang’s research focuses on the following areas: (1) Graph theory and nonlinear-dynamic systems based modeling and integration of omics data and physiological traits. This includes, but not limited to, development of new metrics for “molecular state” definition of a biological system based on omics data;inference of trait-relevant and trait-driven subnetworks of genes and proteins; development and application of new network modeling approaches for time series data. (2) Mathematical modeling of human physiology. In the past her group has developed a multi-scale mathematical model of glucose tolerance, and of the interaction between the insulin-secreting pancreatic islet beta cells and the immune system. The modeling work was successfully integrated with efforts in the first direction, and the genetic study of type 1 diabetes. Such integration led to the identification of new candidate disease genes, and with collaborators the prediction was validated in a large human cohort obtained in Finland. Currently Dr. Wang’s group is extendingsuch effort to modeling the structure and function of the mitochondria network.