Dr. Swati Dadhich-Mandal is endlessly fascinated by science as today we are seeing scientific and technological advances like never before. Physics, chemistry and biology have come together to make the world around us and turning discovery into health. During PhD at JNU, New Delhi, she got trained in Molecular parasitology and learnt how parasites develop drug resistance. I worked with clinical isolates of protozoan parasite Leishmania and their mechanism for antimony drug resistance and developed a high-throughput assay for in vivo drug screening and proteomic platform for biomarker identification (IJEB, 2009; JAC 2010; AAC 2010; MBP 2011). She found that Polycationic amines (aka polyamines) and their biosynthetic enzymes play an important role in parasite’s drug resistance (PLos one 2011, Amino acids 2010). To understand the mammalian (host) polyamines biochemistry and their regulation, she joined National institutes of health in 2011 and within two years we reported that the primary function of these polycationic polyamines is in mammalian translation initiation (PNAS, 2013) and their depletion leads to apoptosis (Biochem J, 2015). Her personal expertise and research interests are in applying genomic & proteomic technologies to increase understanding of molecular mechanisms underlying disease pathogenesis, with a focus on host parasite interaction.
Proteomics; Microarray; High throughput drug screening; Biochemistry and Molecular Biology.