DR. Samiksha Ghimire is currently pursuing a doctorate degree (2015-2019) on improving the diagnosis and treatment of tuberculosis by evaluating new diagnostics and therapeutic strategies, esp. evaluation of PK/PD based dosing strategies to increase efficacy, reduce toxicity and prevent development of drug resistance. The group at Clinical Pharmacy and Pharmacology department in University Medical Center Groningen whom she works with, takes a multi-disciplinary approach ((clinical pharmacokinetics /pharmacodynamics (PK/PD), immunological) to improving the diagnosis and treatment of infectious disease (TB, HIV/AIDS and fungal diseases). She obtained a European Master’s degree in Medical, Pharmaceutical Sciences from University of Groningen, specializing in toxicology and drug disposition track in 2015. As of yet, she has published four papers in Q1 journals. Two as a first author: on pharmacokinetic/pharmacodynamic based dose optimization of levofloxacin in the treatment of MDR-TB; and an editorial letter proposing World Health Organization to organize the logistics for therapeutic drug monitoring (TDM) in a similar way as for TB diagnostics, to make TDM an attainable goal in high incidence resource constrained settings. Furthermore, she has a research experience predicting drug induced cholestatic injury in rat precision cut liver slices.
She received her undergraduate degree in Human Biology with honors distinction (2010) from Kathmandu University, Nepal. After graduation, she joined Kathmandu University Medical School as a “graduate teaching assistant” where she taught nursing students’ subjects related to Clinical Pharmacology (2010-2013).
Conducting clinical trials; Pharmacokinetic/ Pharmacodynamic based dose optimization; Therapeutic drug monitoring; Clinical pharmacology of TB drugs; Development of drug resistance (Inadequate dosing and Medical microbiology); Analytical chromatograpy techniques (LC-MS, LC-MS/MS); Slicing techniques for precision cut liver slices; Sterile cell handling; Tissue culture; In-vitro cleavages; Extraction techniques; Bio-assays.